DegronMD

Uniprot ID: P01375

Source protein: Tumor necrosis factor

Source gene: TNF

Class: DEG_SPOP_SBC_1

Location: 77:81

E3 ligase: SPOP

DEGRON score: 0.5812

ASA_SCORE: 94.38

COIL: 0.8146

CONS_SCORE: 0.5319

DSS_SCORE: 0.5044

HELIX: 0.1618

FCONS_SCORE: 1.0992

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P88L	TCGA-19-5956	GBM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1389
p.P88L	DO13863	GBM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1389
p.A74V	TCGA-98-8021	LUSC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.25
p.A74V	DO27468	LUSC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.R82Q	TCGA-EJ-8474	PRAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.3056
p.R82Q	TCGA-XF-A9SZ	BLCA	TCGA	VRSSS	DEG_SPOP_SBC_1	0.3056
p.R82Q	DO51919	BLCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.3056
p.R82Q	DO48537	PRAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.3056
p.L73V	DO50668	ORCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.L73V	DO50723	ORCA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.P84L	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.P84L	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.P84L	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.P84L	SIDM00948	Burkitt's Lymphoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.P84L	SIDM00146	Breast Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.P84L	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.S79L	SIDM01175	Other Sarcomas	GDSC	VRSSS	DEG_SPOP_SBC_1	0.7667
p.S79L	ACH-002309	Sarcoma	CCLE	VRSSS	DEG_SPOP_SBC_1	0.7667
p.S79L	SW684	soft_tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.7667
p.S85T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.S85T	ACH-002222	Leukemia	CCLE	VRSSS	DEG_SPOP_SBC_1	0.2222
p.S85T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.S80P	SIDM01665	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.6752
p.S80P	ACH-000089	Colon/Colorectal Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons