DegronMD

Uniprot ID: Q70CQ4

Source protein: Ubiquitin carboxyl-terminal hydrolase 31

Source gene: USP31

Class: DEG_SPOP_SBC_1

Location: 1019:1023

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 98.88

COIL: 0.935

CONS_SCORE: 0.2534

DSS_SCORE: 0.7612

HELIX: 0.036

FCONS_SCORE: 1.0501

RIG_SCORE: 0.5698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1025G	TCGA-A6-5666	COAD	TCGA	PESTT	DEG_SPOP_SBC_1	0.2778
p.R1025G	DO9482	COAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.2778
p.E1020D	TCGA-BS-A0UV	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	0.5647
p.E1020D	DO42793	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	0.5647
p.A1016T	SIDM01113	Other Sarcomas	GDSC	PESTT	DEG_SPOP_SBC_1	0.25
p.A1016T	ACH-000939	Sarcoma	CCLE	PESTT	DEG_SPOP_SBC_1	0.25
p.A1016T	SK-UT-1	soft_tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	0.25
p.L1015V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PESTT	DEG_SPOP_SBC_1	0.2222
p.L1015V	ACH-001738	Leukemia	CCLE	PESTT	DEG_SPOP_SBC_1	0.2222
p.L1015V	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons