DegronMD - Q14687(GSE1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S43N	TCGA-AJ-A3BH	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.3056
p.S43N	DO41638	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.3056
p.A447T	TCGA-BR-7707	STAD	TCGA	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.0556
p.A447T	DO38487	STAD	ICGC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.0556
p.P533Q	TCGA-G7-6797	KIRP	TCGA	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.P533Q	DO20917	KIRP	ICGC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.V547M	DO10443	COAD	ICGC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.3056
p.S51L	DO228581	GACA	ICGC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.25
p.P454L	DO229505	LAML	ICGC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.25
p.P454L	SIDM01578	Bladder Carcinoma	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.25
p.S47I	DO228978	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.7341
p.G473V	DO229022	LICA	ICGC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.0833
p.A55S	DO229032	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1389
p.A54S	DO229045	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1667
p.R552H	DO229051	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1667
p.I469T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1944
p.I469T	ACH-000981	Leukemia	CCLE	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1944
p.I469T	DND-41	haematopoietic and lymphoid tissue	COSMIC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1944
p.A49V	SIDM00571	Pancreatic Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.3056
p.S467N	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.25
p.S467N	ACH-000953	Leukemia	CCLE	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.25
p.S467N	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.25
p.P448L	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.0833
p.A45T	ACH-000960	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	44:48	Mutation altering degron motif	0.6028
p.I474V	ACH-000982	Colon/Colorectal Cancer	CCLE	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.0556
p.P471H	SK-MEL-3	skin	COSMIC	PVPTPHHT	DEG_SCF_FBW7_1	457:464	Mutation rewiring degron network	0.1389
p.H535L	OV-56	ovary	COSMIC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1389
p.L58F	NCI-H835	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0556
p.V552M	DMS-114	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1667
p.V552M	COLO-783	skin	COSMIC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1667
p.P39L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.1944
p.N35S	SCC90	upper aerodigestive tract	COSMIC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.0833
p.L52P	SNU-1040	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.2222
p.R51C	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	44:48	Mutation rewiring degron network	0.25
p.R535Q	SNU-1040	large intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GSE1

UniProt ID: Q14687

Entrez ID: 23199

Protein name: Genetic suppressor element 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GSE1 in