DegronMD

Uniprot ID: Q14687

Source protein: Genetic suppressor element 1

Source gene: GSE1

Class: DEG_SCF_FBW7_1

Location: 457:464

E3 ligase: FBXW7

DEGRON score: 0.9584

ASA_SCORE: 97.7

COIL: 0.956

CONS_SCORE: 0.3891

DSS_SCORE: 0.6206

HELIX: 0.0166

FCONS_SCORE: 0.7338

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A447T	TCGA-BR-7707	STAD	TCGA	PVPTPHHT	DEG_SCF_FBW7_1	0.0556
p.A447T	DO38487	STAD	ICGC	PVPTPHHT	DEG_SCF_FBW7_1	0.0556
p.P454L	DO229505	LAML	ICGC	PVPTPHHT	DEG_SCF_FBW7_1	0.25
p.P454L	SIDM01578	Bladder Carcinoma	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	0.25
p.G473V	DO229022	LICA	ICGC	PVPTPHHT	DEG_SCF_FBW7_1	0.0833
p.I469T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	0.1944
p.I469T	ACH-000981	Leukemia	CCLE	PVPTPHHT	DEG_SCF_FBW7_1	0.1944
p.I469T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPHHT	DEG_SCF_FBW7_1	0.1944
p.S467N	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	0.25
p.S467N	ACH-000953	Leukemia	CCLE	PVPTPHHT	DEG_SCF_FBW7_1	0.25
p.S467N	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PVPTPHHT	DEG_SCF_FBW7_1	0.25
p.P448L	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	PVPTPHHT	DEG_SCF_FBW7_1	0.0833
p.I474V	ACH-000982	Colon/Colorectal Cancer	CCLE	PVPTPHHT	DEG_SCF_FBW7_1	0.0556
p.P471H	SK-MEL-3	skin	COSMIC	PVPTPHHT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14687	Genetic suppressor element 1	DEG_SCF_FBW7_1	457:464	PVPTPHHT	FBXW7	0.9584	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons