DegronMD

Uniprot ID: Q14687

Source protein: Genetic suppressor element 1

Source gene: GSE1

Class: DEG_SPOP_SBC_1

Location: 542:546

E3 ligase: SPOP

DEGRON score: 0.997

ASA_SCORE: 99.6

COIL: 0.9374

CONS_SCORE: 0.4785

DSS_SCORE: 0.8856

HELIX: 0.0424

FCONS_SCORE: 1.0375

RIG_SCORE: 0.517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P533Q	TCGA-G7-6797	KIRP	TCGA	PESTT	DEG_SPOP_SBC_1	0.0833
p.P533Q	DO20917	KIRP	ICGC	PESTT	DEG_SPOP_SBC_1	0.0833
p.V547M	DO10443	COAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.3056
p.R552H	DO229051	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.1667
p.H535L	OV-56	ovary	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1389
p.V552M	DMS-114	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1667
p.V552M	COLO-783	skin	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1667
p.R535Q	SNU-1040	large_intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons