DegronMD - Q14242(SELPLG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T73M	TCGA-77-8153	LUSC	TCGA	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation blocking phosphorylation signal	0.7222
p.T73M	TCGA-77-8153	LUSC	TCGA	PESTT	DEG_SPOP_SBC_1	78:82	Mutation blocking phosphorylation signal	0.6389
p.T73M	DO45426	LUSC	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation blocking phosphorylation signal	0.7222
p.T73M	DO45426	LUSC	ICGC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation blocking phosphorylation signal	0.6389
p.G90V	TCGA-ER-A19C	SKCM	TCGA	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.G90V	TCGA-ER-A19C	SKCM	TCGA	PESTT	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.G90V	DO47353	SKCM	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.G90V	DO47353	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1111
p.D66Y	TCGA-VQ-A8P2	STAD	TCGA	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.D66Y	DO51761	STAD	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.M78I	DO229016	COCA	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation altering degron motif	0.7618
p.M78I	DO229016	COCA	ICGC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7618
p.M78I	DO229003	COCA	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation altering degron motif	0.7618
p.M78I	DO229003	COCA	ICGC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7618
p.M78I	DO229005	COCA	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation altering degron motif	0.7618
p.M78I	DO229005	COCA	ICGC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7618
p.M78I	DO228941	LICA	ICGC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation altering degron motif	0.7618
p.M78I	DO228941	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation altering degron motif	0.7618
p.D66E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.D66E	ACH-000809	Esophageal Cancer	CCLE	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.D66E	KYSE-410	oesophagus	COSMIC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833
p.R89H	PANC-10-05	pancreas	COSMIC	PGTPEST	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.1111
p.R89H	PANC-10-05	pancreas	COSMIC	PESTT	DEG_SPOP_SBC_1	78:82	Mutation rewiring degron network	0.1389

Kaplan plot for SELPLG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SELPLG

UniProt ID: Q14242

Entrez ID: 6404

Protein name: P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SELPLG in