DegronMD

Uniprot ID: Q14242

Source protein: P-selectin glycoprotein ligand 1

Source gene: SELPLG

Class: DEG_SCF_FBW7_1

Location: 75:81

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 90.0857

COIL: 0.9403

CONS_SCORE: 0.6099

DSS_SCORE: 0.8051

HELIX: 0.0177

FCONS_SCORE: 1.2156

RIG_SCORE: 0.5975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T73M	TCGA-77-8153	LUSC	TCGA	PGTPEST	DEG_SCF_FBW7_1	0.7222
p.T73M	DO45426	LUSC	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.7222
p.G90V	TCGA-ER-A19C	SKCM	TCGA	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.G90V	DO47353	SKCM	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.D66Y	TCGA-VQ-A8P2	STAD	TCGA	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.D66Y	DO51761	STAD	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.M78I	DO229016	COCA	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.7618
p.M78I	DO229003	COCA	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.7618
p.M78I	DO229005	COCA	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.7618
p.M78I	DO228941	LICA	ICGC	PGTPEST	DEG_SCF_FBW7_1	0.7618
p.D66E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.D66E	ACH-000809	Esophageal Cancer	CCLE	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.D66E	KYSE-410	oesophagus	COSMIC	PGTPEST	DEG_SCF_FBW7_1	0.0833
p.R89H	PANC-10-05	pancreas	COSMIC	PGTPEST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14242	P-selectin glycoprotein ligand 1	DEG_SCF_FBW7_1	75:81	PGTPEST	FBXW7	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons