DegronMD - Q13303(KCNAB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R11W	TCGA-AP-A1DV	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2222
p.R11W	DO43186	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2222
p.S7C	TCGA-R6-A6XG	ESCA	TCGA	PESTT	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7541
p.R16W	DO227948	BRCA	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	DO23942	LUAD	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	DO42713	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	SIDM00568	Gastric Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	SIDM00556	Neuroblastoma	GDSC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	SIDM00817	Kidney Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	ACH-000227	Neuroblastoma	CCLE	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	ACH-000247	Gastric Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	KP-N-YN	autonomic ganglia	COSMIC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.R16W	OCUM-1	stomach	COSMIC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.S14L	DO233636	GACA	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation blocking phosphorylation signal	0.5833
p.R12Q	DO35613	PBCA	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1944
p.R12Q	DO38479	STAD	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1944
p.R11Q	DO230690	PRAD	ICGC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2222
p.R12W	SIDM02059	Colorectal Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1944
p.T7M	SIDM00217	Colorectal Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.8534
p.T7M	ACH-000999	Colon/Colorectal Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.8534
p.T7M	SNU-1040	large intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.8534
p.I14M	5637	urinary tract	COSMIC	PESTT	DEG_SPOP_SBC_1	3:7	Mutation blocking phosphorylation signal	0.5833

Kaplan plot for KCNAB2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNAB2

UniProt ID: Q13303

Entrez ID: 8514

Protein name: Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KCNAB2 in