DegronMD

Uniprot ID: Q13303

Source protein: Voltage-gated potassium channel subunit beta-2

Source gene: KCNAB2

Class: DEG_SPOP_SBC_1

Location: 3:7

E3 ligase: SPOP

DEGRON score: 0.9349

ASA_SCORE: 85.52

COIL: 0.913

CONS_SCORE: 0.3292

DSS_SCORE: 0.8304

HELIX: 0.052

FCONS_SCORE: 0.9953

RIG_SCORE: 0.671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11W	TCGA-AP-A1DV	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	0.2222
p.R11W	DO43186	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	0.2222
p.S7C	TCGA-R6-A6XG	ESCA	TCGA	PESTT	DEG_SPOP_SBC_1	0.7541
p.R16W	DO227948	BRCA	ICGC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	DO23942	LUAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	DO42713	UCEC	ICGC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	SIDM00568	Gastric Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	SIDM00556	Neuroblastoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	SIDM00817	Kidney Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	ACH-000227	Neuroblastoma	CCLE	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	ACH-000247	Gastric Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	KP-N-YN	autonomic_ganglia	COSMIC	PESTT	DEG_SPOP_SBC_1	0.0833
p.R16W	OCUM-1	stomach	COSMIC	PESTT	DEG_SPOP_SBC_1	0.0833
p.S14L	DO233636	GACA	ICGC	PESTT	DEG_SPOP_SBC_1	0.5833
p.R12Q	DO35613	PBCA	ICGC	PESTT	DEG_SPOP_SBC_1	0.1944
p.R12Q	DO38479	STAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.1944
p.R11Q	DO230690	PRAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.2222
p.R12W	SIDM02059	Colorectal Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.1944
p.T7M	SIDM00217	Colorectal Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.8534
p.T7M	ACH-000999	Colon/Colorectal Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	0.8534
p.T7M	SNU-1040	large_intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	0.8534
p.I14M	5637	urinary_tract	COSMIC	PESTT	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons