DegronMD - Q9P1Z2(CALCOCO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R480C	TCGA-B5-A5OC	UCEC	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.719
p.R480C	TCGA-FI-A2D5	UCEC	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.719
p.R480C	DO52405	UCEC	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.719
p.R480C	DO41331	UCEC	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.719
p.R480C	SIDM00334	Endometrial Carcinoma	GDSC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.719
p.R480C	ACH-000879	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.719
p.E492V	TCGA-BR-6458	STAD	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.0833
p.E492V	DO38296	STAD	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.0833
p.T473I	TCGA-BS-A0U8	UCEC	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.2778
p.T473I	DO41380	UCEC	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.2778
p.K486N	TCGA-EE-A29E	SKCM	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation substituting flanking lysine	0.3611
p.K486N	DO37831	SKCM	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation substituting flanking lysine	0.3611
p.E471A	TCGA-GM-A2DL	BRCA	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.2222
p.E471A	DO1497	BRCA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.2222
p.R470L	TCGA-GN-A266	SKCM	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1944
p.R470L	DO37432	SKCM	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1944
p.L475M	TCGA-VN-A88M	PRAD	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.5999
p.L475M	DO49857	PRAD	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.5999
p.V69M	TCGA-VQ-A8P2	STAD	TCGA	PESTT	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.3056
p.V69M	DO51761	STAD	ICGC	PESTT	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.3056
p.V69M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.3056
p.R480H	DO225337	BRCA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7133
p.Q490K	DO228974	LICA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1389
p.Q84K	DO228976	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556
p.Q490H	DO232224	PBCA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1389
p.R476Q	SIDM00596	Endometrial Carcinoma	GDSC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.R476Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.R476Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.R476Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.R476Q	HEC-1	endometrium	COSMIC	LRSALRVLQ	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.D60H	ACH-001645	Skin Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	70:74	Mutation rewiring degron network	0.0556

Kaplan plot for CALCOCO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CALCOCO1

UniProt ID: Q9P1Z2

Entrez ID: 57658

Protein name: Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CALCOCO1 in