DegronMD

Uniprot ID: Q9P1Z2

Source protein: Calcium-binding and coiled-coil domain-containing protein 1

Source gene: CALCOCO1

Class: DEG_APCC_DBOX_1

Location: 475:483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6499

ASA_SCORE: 92.2

COIL: 0.0139

CONS_SCORE: 0.5473

DSS_SCORE: 0.3157

HELIX: 0.9869

FCONS_SCORE: 1.0571

RIG_SCORE: 0.7814

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R476Q	SIDM00596	Endometrial Carcinoma	GDSC	LRSALRVLQ	DEG_APCC_DBOX_1	0.7329
p.R476Q	ACH-000941	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	0.7329
p.R476Q	ACH-000954	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	0.7329
p.R476Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	0.7329
p.R476Q	HEC-1	endometrium	COSMIC	LRSALRVLQ	DEG_APCC_DBOX_1	0.7329
p.R480C	TCGA-B5-A5OC	UCEC	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.719
p.R480C	TCGA-FI-A2D5	UCEC	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.719
p.R480C	DO52405	UCEC	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.719
p.R480C	DO41331	UCEC	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.719
p.R480C	SIDM00334	Endometrial Carcinoma	GDSC	LRSALRVLQ	DEG_APCC_DBOX_1	0.719
p.R480C	ACH-000879	Endometrial/Uterine Cancer	CCLE	LRSALRVLQ	DEG_APCC_DBOX_1	0.719
p.R480H	DO225337	BRCA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.7133
p.L475M	TCGA-VN-A88M	PRAD	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.5999
p.L475M	DO49857	PRAD	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.5999
p.K486N	TCGA-EE-A29E	SKCM	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.3611
p.K486N	DO37831	SKCM	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.3611
p.T473I	TCGA-BS-A0U8	UCEC	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.2778
p.T473I	DO41380	UCEC	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.2778
p.E471A	TCGA-GM-A2DL	BRCA	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.2222
p.E471A	DO1497	BRCA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.2222
p.R470L	TCGA-GN-A266	SKCM	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.1944
p.R470L	DO37432	SKCM	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.1944
p.Q490K	DO228974	LICA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.1389
p.Q490H	DO232224	PBCA	ICGC	LRSALRVLQ	DEG_APCC_DBOX_1	0.1389
p.E492V	TCGA-BR-6458	STAD	TCGA	LRSALRVLQ	DEG_APCC_DBOX_1	0.0833

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Drug responses associated with CALCOCO1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LRSALRVLQ

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_APCC_DBOX_1	475:483	LRSALRVLQ	APC,CDC20,FZR1	0.6499	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRSALRVLQ

Degron related mutations and impact score

Drug responses associated with CALCOCO1 mutations

All proteins holding degron of LRSALRVLQ