DegronMD

Uniprot ID: Q9P1Z2

Source protein: Calcium-binding and coiled-coil domain-containing protein 1

Source gene: CALCOCO1

Class: DEG_SPOP_SBC_1

Location: 70:74

E3 ligase: SPOP

DEGRON score: 0.6507

ASA_SCORE: 78.7

COIL: 0.8396

CONS_SCORE: 0.5765

DSS_SCORE: 0.3148

HELIX: 0.0528

FCONS_SCORE: 0.8856

RIG_SCORE: 0.7029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V69M	TCGA-VQ-A8P2	STAD	TCGA	PESTT	DEG_SPOP_SBC_1	0.3056
p.V69M	DO51761	STAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.3056
p.V69M	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.3056
p.Q84K	DO228976	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.0556
p.D60H	ACH-001645	Skin Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons