DegronMD

Uniprot ID: O95359

Source protein: Transforming acidic coiled-coil-containing protein 2

Source gene: TACC2

Class: DEG_SPOP_SBC_1

Location: 1956:1960

E3 ligase: SPOP

DEGRON score: 0.9713

ASA_SCORE: 88.42

COIL: 0.932

CONS_SCORE: 0.6327

DSS_SCORE: 0.7998

HELIX: 0.0194

FCONS_SCORE: 1.0053

RIG_SCORE: 0.5566

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1955N	TCGA-2G-AAKH	TGCT	TCGA	PESTT	DEG_SPOP_SBC_1	0.3056
p.P1969S	TCGA-AP-A5FX	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	0.0833
p.P1970Q	TCGA-D3-A2JK	SKCM	TCGA	PESTT	DEG_SPOP_SBC_1	0.0556
p.E1951D	TCGA-FI-A2D5	UCEC	TCGA	PESTT	DEG_SPOP_SBC_1	0.1944
p.G1957V	DO229006	LICA	ICGC	PESTT	DEG_SPOP_SBC_1	0.7532
p.G1946V	DO23624	LUAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.5
p.G1957D	DO37429	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	0.7198
p.G1957D	DO38159	SKCM	ICGC	PESTT	DEG_SPOP_SBC_1	0.7198
p.R1959W	YT	haematopoietic_and_lymphoid_tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	0.8634
p.R1959W	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PESTT	DEG_SPOP_SBC_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons