DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 201:205

E3 ligase: SPOP

DEGRON score: 0.638

ASA_SCORE: 97.42

COIL: 0.8618

CONS_SCORE: 0.6167

DSS_SCORE: 0.6989

HELIX: 0.0158

FCONS_SCORE: 1.0382

RIG_SCORE: 0.6262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E202K	TCGA-BA-A6DJ	HNSC	TCGA	PESTT	DEG_SPOP_SBC_1	0.591
p.E202K	DO52034	HNSC	ICGC	PESTT	DEG_SPOP_SBC_1	0.591
p.G214V	TCGA-CD-8535	STAD	TCGA	PESTT	DEG_SPOP_SBC_1	0.0833
p.G214V	DO47741	STAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.0833
p.S195R	TCGA-VQ-A94R	STAD	TCGA	PESTT	DEG_SPOP_SBC_1	0.1667
p.S195R	DO222372	STAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.1667
p.T199I	DO234321	ESAD	ICGC	PESTT	DEG_SPOP_SBC_1	0.2778
p.S196L	DO220877	MELA	ICGC	PESTT	DEG_SPOP_SBC_1	0.1944
p.S203N	DO220911	MELA	ICGC	PESTT	DEG_SPOP_SBC_1	0.7069
p.S212N	DO222837	MELA	ICGC	PESTT	DEG_SPOP_SBC_1	0.5833
p.A194E	SIDM00506	Small Cell Lung Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.1389
p.A194E	COR-L88	lung	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1389
p.A194T	SIDM00118	Colorectal Carcinoma	GDSC	PESTT	DEG_SPOP_SBC_1	0.1389
p.A194T	ACH-001081	Colon/Colorectal Cancer	CCLE	PESTT	DEG_SPOP_SBC_1	0.1389
p.A194T	HCC2998	large_intestine	COSMIC	PESTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	1956:1960	PESTT	SPOP	0.9713	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	141:145	PESTT	SPOP	0.838	More...
Q13303	Voltage-gated potassium channel subunit beta-2	DEG_SPOP_SBC_1	3:7	PESTT	SPOP	0.9349	More...
Q14242	P-selectin glycoprotein ligand 1	DEG_SPOP_SBC_1	78:82	PESTT	SPOP	0.9598	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	542:546	PESTT	SPOP	0.997	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	201:205	PESTT	SPOP	0.638	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1019:1023	PESTT	SPOP	0.9963	More...
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1	DEG_SPOP_SBC_1	70:74	PESTT	SPOP	0.6507	More...
Q9ULL0	Acrosomal protein KIAA1210	DEG_SPOP_SBC_1	1104:1108	PESTT	SPOP	0.985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons