DegronMD

Uniprot ID: Q70CQ4

Source protein: Ubiquitin carboxyl-terminal hydrolase 31

Source gene: USP31

Class: DEG_SCF_TRCP1_1

Location: 1317:1323

E3 ligase: BTRC

DEGRON score: 0.9683

ASA_SCORE: 78.9

COIL: 0.9586

CONS_SCORE: 0.2337

DSS_SCORE: 0.754

HELIX: 0.0204

FCONS_SCORE: 0.9461

RIG_SCORE: 0.5305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1324L	TCGA-60-2711	LUSC	TCGA	DSGVPSS	DEG_SCF_TRCP1_1	0.3056
p.P1324L	DO48215	ESCA	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	0.3056
p.P1324L	DO26987	LUSC	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	0.3056
p.P1321L	TCGA-EE-A29C	SKCM	TCGA	DSGVPSS	DEG_SCF_TRCP1_1	0.6471
p.P1321L	DO222727	MELA	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	0.6471
p.P1321L	DO38028	SKCM	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	0.6471
p.P1321S	TCGA-FW-A5DY	SKCM	TCGA	DSGVPSS	DEG_SCF_TRCP1_1	0.5641
p.P1321S	DO47257	SKCM	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	0.5641
p.A1330S	DO229058	LICA	ICGC	DSGVPSS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SCF_TRCP1_1	1317:1323	DSGVPSS	BTRC	0.9683	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons