DegronMD

Uniprot ID: Q70CQ4

Source protein: Ubiquitin carboxyl-terminal hydrolase 31

Source gene: USP31

Class: DEG_SCF_FBW7_1

Location: 200:207

E3 ligase: FBXW7

DEGRON score: 0.7999

ASA_SCORE: 66.7

COIL: 0.8498

CONS_SCORE: 0.3999

DSS_SCORE: 0.2219

HELIX: 0.0629

FCONS_SCORE: 0.8278

RIG_SCORE: 0.801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K216N	TCGA-AP-A056	UCEC	TCGA	LEYTPQHS	DEG_SCF_FBW7_1	0.1944
p.K216N	DO43971	UCEC	ICGC	LEYTPQHS	DEG_SCF_FBW7_1	0.1944
p.K216N	SIDM00590	Oral Cavity Carcinoma	GDSC	LEYTPQHS	DEG_SCF_FBW7_1	0.1944
p.K216N	HSC-2	upper_aerodigestive_tract	COSMIC	LEYTPQHS	DEG_SCF_FBW7_1	0.1944
p.L193R	ACH-001517	Endometrial/Uterine Cancer	CCLE	LEYTPQHS	DEG_SCF_FBW7_1	0.1389
p.S207R	HCT-15	large_intestine	COSMIC	LEYTPQHS	DEG_SCF_FBW7_1	0.7427
p.S213G	ECC10	stomach	COSMIC	LEYTPQHS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SCF_FBW7_1	200:207	LEYTPQHS	FBXW7	0.7999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons