DegronMD

Uniprot ID: Q70CQ4

Source protein: Ubiquitin carboxyl-terminal hydrolase 31

Source gene: USP31

Class: DEG_APCC_DBOX_1

Location: 808:816

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9949

ASA_SCORE: 94.8667

COIL: 0.7423

CONS_SCORE: 0.3499

DSS_SCORE: 0.4998

HELIX: 0.2287

FCONS_SCORE: 1.1161

RIG_SCORE: 0.6731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E820D	TCGA-AP-A0LM	UCEC	TCGA	RRTSLASLS	DEG_APCC_DBOX_1	0.2222
p.E820D	DO43306	UCEC	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	0.2222
p.L812M	DO233760	GACA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	0.711
p.A799D	DO229018	LICA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	0.0833
p.S814L	DO229052	LICA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	0.7667
p.S803F	DO220912	MELA	ICGC	RRTSLASLS	DEG_APCC_DBOX_1	0.1944
p.S818F	SIDM01175	Other Sarcomas	GDSC	RRTSLASLS	DEG_APCC_DBOX_1	0.2778
p.S818F	ACH-002309	Sarcoma	CCLE	RRTSLASLS	DEG_APCC_DBOX_1	0.2778
p.S818F	SW684	soft_tissue	COSMIC	RRTSLASLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_APCC_DBOX_1	808:816	RRTSLASLS	APC,CDC20,FZR1	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons