DegronMD

Uniprot ID: Q70CQ4

Source protein: Ubiquitin carboxyl-terminal hydrolase 31

Source gene: USP31

Class: DEG_SPOP_SBC_1

Location: 778:782

E3 ligase: SPOP

DEGRON score: 0.7948

ASA_SCORE: 71

COIL: 0.8838

CONS_SCORE: 0.4332

DSS_SCORE: 0.2894

HELIX: 0.0878

FCONS_SCORE: 1.1561

RIG_SCORE: 0.6525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S770L	TCGA-AC-A23H	BRCA	TCGA	AGSTS	DEG_SPOP_SBC_1	0.1111
p.S770L	DO2401	BRCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.1111
p.S783F	TCGA-E5-A2PC	BLCA	TCGA	AGSTS	DEG_SPOP_SBC_1	0.3056
p.S783F	DO702	BLCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.S783F	DO220851	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.P769S	TCGA-EB-A3Y7	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	0.0833
p.P769S	DO37499	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0833
p.R792Q	TCGA-EO-A22U	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792Q	DO43755	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792Q	SIDM00121	T-Lymphoblastic Leukemia	GDSC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792Q	ACH-001738	Leukemia	CCLE	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792Q	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.S784F	TCGA-FW-A3R5	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	0.2778
p.S784F	DO37406	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.R792W	DO229453	SKCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792W	SIDM00602	Gastric Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792W	ACH-000919	Gastric Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	0.0556
p.R792W	IM-95	stomach	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.W789R	SIDM01090	Colorectal Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.1389
p.W789R	ACH-000943	Colon/Colorectal Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	0.1389
p.W789R	RKO	large_intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.1389
p.P769L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.0833
p.P769L	ACH-000785	Lung Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	0.0833
p.P769L	NCI-H2126	lung	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00567	Nucleolar protein 56	DEG_SPOP_SBC_1	526:530	AGSTS	SPOP	0.9464	More...
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	959:963	AGSTS	SPOP	0.9989	More...
O76080	AN1-type zinc finger protein 5	DEG_SPOP_SBC_1	80:84	AGSTS	SPOP	0.9883	More...
P03372	Estrogen receptor	DEG_SPOP_SBC_1	571:575	AGSTS	SPOP	0.9845	More...
P15923	Transcription factor E2-alpha	DEG_SPOP_SBC_1	453:457	AGSTS	SPOP	0.9279	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	621:625	AGSTS	SPOP	0.9979	More...
Q14186	Transcription factor Dp-1	DEG_SPOP_SBC_1	350:354	AGSTS	SPOP	0.9899	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	778:782	AGSTS	SPOP	0.7948	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	93:97	AGSTS	SPOP	0.9806	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	1280:1284	AGSTS	SPOP	0.8593	More...
Q9BXF6	Rab11 family-interacting protein 5	DEG_SPOP_SBC_1	38:42	AGSTS	SPOP	0.7413	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_SPOP_SBC_1	469:473	AGSTS	SPOP	0.9917	More...
Q9NW13	RNA-binding protein 28	DEG_SPOP_SBC_1	642:646	AGSTS	SPOP	0.9698	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	5:9	AGSTS	SPOP	0.7921	More...
Q9Y5Q3	Transcription factor MafB	DEG_SPOP_SBC_1	309:313	AGSTS	SPOP	0.9235	More...
Q86XD8	AN1-type zinc finger protein 4	DEG_SPOP_SBC_1	574:578	AGSTS	SPOP	0.9676	More...
Q8IYL3	UPF0688 protein C1orf174	DEG_SPOP_SBC_1	33:37	AGSTS	SPOP	0.9615	More...
Q86X59	Putative uncharacterized protein LINC02875	DEG_SPOP_SBC_1	166:170	AGSTS	SPOP	0.9773	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSTS

Degron related mutations and impact score

Drug responses associated with USP31 mutations

All proteins holding degron of AGSTS