DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SPOP_SBC_1

Location: 959:963

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 73.18

COIL: 0.9382

CONS_SCORE: 0.2681

DSS_SCORE: 0.5218

HELIX: 0.026

FCONS_SCORE: 1.0179

RIG_SCORE: 0.6213

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S961N	TCGA-D5-6930	COAD	TCGA	AGSTS	DEG_SPOP_SBC_1	0.818
p.S961N	DO10550	COAD	ICGC	AGSTS	DEG_SPOP_SBC_1	0.818
p.P961L	ACH-000946	Endometrial/Uterine Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	0.7582
p.P957L	ACH-001057	Lymphoma	CCLE	AGSTS	DEG_SPOP_SBC_1	0.7222
p.G953R	TCGA-AD-5900	COAD	TCGA	AGSTS	DEG_SPOP_SBC_1	0.1667
p.G953R	DO8514	COAD	ICGC	AGSTS	DEG_SPOP_SBC_1	0.1667
p.P952S	TCGA-D3-A8GI	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	0.1389
p.P952S	DO50284	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	0.1389
p.G952C	ACH-000180	Non-Cancerous	CCLE	AGSTS	DEG_SPOP_SBC_1	0.1389
p.A950D	TCGA-2W-A8YY	CESC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.0833
p.A950D	DO223732	CESC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0833
p.G972C	TCGA-BQ-7049	KIRP	TCGA	AGSTS	DEG_SPOP_SBC_1	0.0833
p.G972C	DO20853	KIRP	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0833
p.G972S	DO45169	LIRI	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0833
p.S949N	SIDM00422	Hodgkin's Lymphoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.0556
p.S949N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 16 of 16 entries

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Drug responses associated with SEC16A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AGSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XD8	AN1-type zinc finger protein 4	DEG_SPOP_SBC_1	574:578	AGSTS	SPOP	0.9676	More...
O76080	AN1-type zinc finger protein 5	DEG_SPOP_SBC_1	80:84	AGSTS	SPOP	0.9883	More...
P03372	Estrogen receptor	DEG_SPOP_SBC_1	571:575	AGSTS	SPOP	0.9845	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	93:97	AGSTS	SPOP	0.9806	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	621:625	AGSTS	SPOP	0.9979	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	5:9	AGSTS	SPOP	0.7921	More...
O00567	Nucleolar protein 56	DEG_SPOP_SBC_1	526:530	AGSTS	SPOP	0.9464	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	1280:1284	AGSTS	SPOP	0.8593	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_SPOP_SBC_1	469:473	AGSTS	SPOP	0.9917	More...
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	959:963	AGSTS	SPOP	0.9989	More...
Q86X59	Putative uncharacterized protein LINC02875	DEG_SPOP_SBC_1	166:170	AGSTS	SPOP	0.9773	More...
Q9BXF6	Rab11 family-interacting protein 5	DEG_SPOP_SBC_1	38:42	AGSTS	SPOP	0.7413	More...
Q9NW13	RNA-binding protein 28	DEG_SPOP_SBC_1	642:646	AGSTS	SPOP	0.9698	More...
Q14186	Transcription factor Dp-1	DEG_SPOP_SBC_1	350:354	AGSTS	SPOP	0.9899	More...
P15923	Transcription factor E2-alpha	DEG_SPOP_SBC_1	453:457	AGSTS	SPOP	0.9279	More...
Q9Y5Q3	Transcription factor MafB	DEG_SPOP_SBC_1	309:313	AGSTS	SPOP	0.9235	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	778:782	AGSTS	SPOP	0.7948	More...
Q8IYL3	UPF0688 protein C1orf174	DEG_SPOP_SBC_1	33:37	AGSTS	SPOP	0.9615	More...

Showing 1 to 18 of 18 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSTS

Degron related mutations and impact score

Drug responses associated with SEC16A mutations

All proteins holding degron of AGSTS