DegronMD - O15027(SEC16A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1121G	TCGA-05-4397	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.6993
p.S1121G	DO25320	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.6993
p.T443K	TCGA-2G-AAGY	TGCT	TCGA	DTASTGVPDA	DEG_COP1_1	442:451	Mutation altering degron motif	0.6195
p.P2055H	TCGA-2W-A8YY	CESC	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7694
p.P2055H	TCGA-ER-A19P	SKCM	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7694
p.P2055H	DO223732	CESC	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7694
p.P2055H	DO47623	SKCM	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7694
p.A950D	TCGA-2W-A8YY	CESC	TCGA	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.A950D	DO223732	CESC	ICGC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.W2068L	TCGA-55-6979	LUAD	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0556
p.W2068L	DO24110	LUAD	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0556
p.S187I	TCGA-86-8073	LUAD	TCGA	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation blocking phosphorylation signal	0.5556
p.S187I	DO23624	LUAD	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation blocking phosphorylation signal	0.5556
p.P1901S	TCGA-A6-6654	COAD	TCGA	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901S	DO9498	COAD	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1905S	TCGA-AA-3977	COAD	TCGA	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.6752
p.P1905S	DO8730	COAD	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.6752
p.E2044D	TCGA-AA-3984	COAD	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0833
p.E2044D	DO9002	COAD	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0833
p.G953R	TCGA-AD-5900	COAD	TCGA	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1667
p.G953R	DO8514	COAD	ICGC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1667
p.V1348I	TCGA-AJ-A8CW	UCEC	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.5965
p.V1348I	DO52654	MALY	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.5965
p.V1348I	DO52400	UCEC	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.5965
p.Q1896H	TCGA-AP-A0LM	UCEC	TCGA	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.0833
p.Q1896H	DO43306	UCEC	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.0833
p.G1906D	TCGA-B5-A3FC	UCEC	TCGA	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.6087
p.G1906D	DO41871	UCEC	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.6087
p.A1108V	TCGA-BG-A221	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.0833
p.A1108V	DO42384	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.0833
p.D878N	TCGA-BH-A1FM	BRCA	TCGA	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation altering degron motif	0.6932
p.D878N	DO1364	BRCA	ICGC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation altering degron motif	0.6932
p.G972C	TCGA-BQ-7049	KIRP	TCGA	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.G972C	DO20853	KIRP	ICGC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.A199V	TCGA-BS-A0TJ	UCEC	TCGA	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5825
p.A199V	DO42953	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5825
p.E2043K	TCGA-BS-A0UV	UCEC	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0556
p.E2043K	DO42793	UCEC	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0556
p.E2043K	SIDM02013	Colorectal Carcinoma	GDSC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0556
p.P2066R	TCGA-CN-6019	HNSC	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1111
p.P2066R	DO14316	HNSC	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1111
p.A2219T	TCGA-D1-A17Q	UCEC	TCGA	LAPLPIPSNLFV	DEG_ODPH_VHL_1	2218:2229	Mutation altering degron motif	0.7139
p.A2219T	SIDM00537	Colorectal Carcinoma	GDSC	LAPLPIPSNLFV	DEG_ODPH_VHL_1	2218:2229	Mutation altering degron motif	0.7139
p.P952S	TCGA-D3-A8GI	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.P952S	DO50284	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.S961N	TCGA-D5-6930	COAD	TCGA	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.818
p.S961N	DO10550	COAD	ICGC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.818
p.A56T	TCGA-DU-6392	LGG	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1667
p.A56T	DO22237	LGG	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1667
p.P1114T	TCGA-DZ-6135	KIRP	TCGA	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.25
p.P1114T	DO20926	KIRP	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.25
p.G880V	TCGA-EE-A2GH	SKCM	TCGA	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation altering degron motif	0.7532
p.G880V	DO37643	SKCM	ICGC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation altering degron motif	0.7532
p.G887V	TCGA-EE-A2MD	SKCM	TCGA	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.25
p.G887V	DO37851	SKCM	ICGC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.25
p.D53N	TCGA-EE-A2MT	SKCM	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0833
p.D53N	DO50694	ORCA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0833
p.D53N	DO38051	SKCM	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0833
p.G194C	TCGA-ER-A19G	SKCM	TCGA	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.3056
p.G194C	DO47284	SKCM	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.3056
p.K2049Q	TCGA-EY-A1GI	UCEC	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation substituting flanking lysine	0.3333
p.K2049Q	DO41211	UCEC	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation substituting flanking lysine	0.3333
p.S1356I	TCGA-FI-A2D5	UCEC	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation blocking phosphorylation signal	0.6389
p.S1356I	DO41331	UCEC	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation blocking phosphorylation signal	0.6389
p.A200V	TCGA-G7-6795	KIRP	TCGA	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5825
p.A200V	DO20851	KIRP	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.5825
p.A2051T	TCGA-G7-A8LE	KIRP	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2778
p.A2051T	DO51555	KIRP	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2778
p.S2056L	TCGA-GN-A266	SKCM	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7667
p.S2056L	DO37432	SKCM	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7667
p.P205S	TCGA-GN-A26C	SKCM	TCGA	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.2222
p.P205S	DO37782	SKCM	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.2222
p.G876C	TCGA-GN-A26D	SKCM	TCGA	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.2778
p.G876C	DO37480	SKCM	ICGC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.2778
p.E1342K	TCGA-GN-A8LK	SKCM	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation rewiring degron network	0.25
p.E1342K	DO51259	SKCM	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation rewiring degron network	0.25
p.A61V	TCGA-HU-A4H8	STAD	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.A61V	DO47869	STAD	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.F2046C	TCGA-KD-A5QU	SARC	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.F2046C	DO223272	SARC	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.S70L	TCGA-QB-A6FS	SKCM	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.S70L	DO48654	SKCM	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.R1355W	TCGA-QQ-A8VF	SARC	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation rewiring degron network	0.2222
p.R1355W	DO220258	SARC	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation rewiring degron network	0.2222
p.S2062L	TCGA-S5-AA26	BLCA	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2222
p.S2062L	DO51904	BLCA	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2222
p.S2062L	SIDM00973	Melanoma	GDSC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2222
p.S2062L	WM793B	skin	COSMIC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2222
p.P2065L	TCGA-W3-AA1R	SKCM	TCGA	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.P2065L	DO51275	SKCM	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.Q1118K	DO472	BLCA	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.5833
p.F2046L	DO225032	BRCA	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.P76H	DO222414	BTCA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.T68P	DO228799	GACA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7031
p.T68P	DO229350	LAML	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7031
p.G207R	DO233207	GACA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.1667
p.R210Q	DO233882	GACA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.0833
p.A1360T	DO233898	GACA	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation rewiring degron network	0.0833
p.E2044Q	DO233952	GACA	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0833
p.E2044Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0833
p.E2044Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.0833
p.S1121N	DO228215	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.7069
p.R1345Q	DO228941	LICA	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.7329
p.L67M	DO228976	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.5999
p.S79P	DO228976	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0556
p.S79P	DO229027	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0556
p.S79P	ACH-000349	Breast Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0556
p.H1895N	DO228985	LICA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.0556
p.A1108E	DO229015	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.0833
p.D2061E	DO229028	LICA	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.25
p.A1354E	DO229024	LICA	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation rewiring degron network	0.25
p.P54T	DO229026	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1111
p.P2060Q	DO229034	LICA	ICGC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.2778
p.Q1903K	DO229037	LICA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2778
p.D1107E	DO229009	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.0556
p.D201E	DO229008	LICA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.6758
p.G972S	DO45169	LIRI	ICGC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0833
p.S203F	DO229177	LMS	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation blocking phosphorylation signal	0.7222
p.Q1110H	DO52354	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.1389
p.P76S	DO222714	MELA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.P868L	DO222908	MELA	ICGC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.0556
p.Q210K	DO27883	ORCA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.0833
p.N458I	DO51962	PRAD	ICGC	DTASTGVPDA	DEG_COP1_1	442:451	Mutation rewiring degron network	0.1389
p.P1905L	DO219871	SKCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.6471
p.D1897N	DO229268	THCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1111
p.R1917W	DO229250	THCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1667
p.Y199C	DO42023	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7087
p.R198C	DO41871	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.8301
p.V200I	DO43907	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7076
p.G876D	SIDM01953	Colorectal Carcinoma	GDSC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.2778
p.S949N	SIDM00422	Hodgkin's Lymphoma	GDSC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.S949N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.A2234E	SIDM00477	Esophageal Carcinoma	GDSC	VPTPDAE	DEG_SCF_FBW7_2	2229:2235	Mutation altering degron motif	0.659
p.A2234E	OE33	oesophagus	COSMIC	VPTPDAE	DEG_SCF_FBW7_2	2229:2235	Mutation altering degron motif	0.659
p.G887E	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.25
p.P191S	SIDM00523	Small Cell Lung Carcinoma	GDSC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.2222
p.P191S	DMS-53	lung	COSMIC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.2222
p.T2231I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VPTPDAE	DEG_SCF_FBW7_2	2229:2235	Mutation altering degron motif	0.8189
p.T2231I	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VPTPDAE	DEG_SCF_FBW7_2	2229:2235	Mutation altering degron motif	0.8189
p.P2230L	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VPTPDAE	DEG_SCF_FBW7_2	2229:2235	Mutation altering degron motif	0.6471
p.P2230L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VPTPDAE	DEG_SCF_FBW7_2	2229:2235	Mutation altering degron motif	0.6471
p.R1346H	SIDM01110	Hepatocellular Carcinoma	GDSC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.7133
p.R1346H	SK-HEP-1	liver	COSMIC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.7133
p.P1901L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901L	SIDM00971	Breast Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901L	SIDM00875	Breast Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901L	SIDM00808	Burkitt's Lymphoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.P1901L	SIDM01254	Burkitt's Lymphoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2222
p.N2226D	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LAPLPIPSNLFV	DEG_ODPH_VHL_1	2218:2229	Mutation altering degron motif	0.5821
p.P2065S	SIDM01193	Glioma	GDSC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.P2065S	SIDM01323	Oral Cavity Carcinoma	GDSC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.P2065S	U-118-MG	central nervous system	COSMIC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1389
p.S1347N	SIDM01608	Endometrial Carcinoma	GDSC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	1345:1351	Mutation altering degron motif	0.7069
p.G1130C	SIDM01724	Melanoma	GDSC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation rewiring degron network	0.0833
p.A195E	ACH-000162	Lymphoma	CCLE	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7701
p.N2048H	ACH-000165	Non-Cancerous	CCLE	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.1944
p.G952C	ACH-000180	Non-Cancerous	CCLE	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.E877K	ACH-000246	Kidney Cancer	CCLE	DSGENTS	DEG_SCF_TRCP1_1	878:884	Mutation rewiring degron network	0.3056
p.P1900L	ACH-000380	Myeloma	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1944
p.P1900L	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1944
p.F198Y	ACH-000733	Lung Cancer	CCLE	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7528
p.F198Y	NCI-H1838	lung	COSMIC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation altering degron motif	0.7528
p.P55A	ACH-000780	Lung Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.P55A	NCI-H1105	lung	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.K1911E	ACH-000904	Lung Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.7022
p.K1911E	ACH-001362	Lung Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.7022
p.K1911E	NCI-H1770	lung	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation altering degron motif	0.7022
p.P961L	ACH-000946	Endometrial/Uterine Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7582
p.A1121T	ACH-000948	Gastric Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.7139
p.A1121T	ACH-000964	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.7139
p.A1121T	ACH-000989	Colon/Colorectal Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.7139
p.A1121T	SNU-175	large intestine	COSMIC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.7139
p.A1121T	23132-87	stomach	COSMIC	PQSSS	DEG_SPOP_SBC_1	1117:1121	Mutation altering degron motif	0.7139
p.S1903F	ACH-000987	Skin Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2778
p.S1903F	Mewo	skin	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.2778
p.A451T	ACH-000990	Endometrial/Uterine Cancer	CCLE	DTASTGVPDA	DEG_COP1_1	442:451	Mutation altering degron motif	0.7139
p.L71H	ACH-000999	Colon/Colorectal Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.2778
p.L71H	SNU-1040	large intestine	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.2778
p.P435L	ACH-000999	Colon/Colorectal Cancer	CCLE	DTASTGVPDA	DEG_COP1_1	442:451	Mutation rewiring degron network	0.1389
p.P957L	ACH-001057	Lymphoma	CCLE	AGSTS	DEG_SPOP_SBC_1	959:963	Mutation blocking phosphorylation signal	0.7222
p.T1898R	ACH-001065	Breast Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1389
p.T1898R	EVSA-T	breast	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1389
p.P70S	ACH-001190	Skin Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.P70S	SK-MEL-2	skin	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.3056
p.T1898K	ACH-001484	Leukemia	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1389
p.T1898K	ACH-001485	Leukemia	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1389
p.T1898M	ACH-001517	Endometrial/Uterine Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1389
p.T1898M	HEC-1	endometrium	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1389
p.T2053I	ACH-002059	Leukemia	CCLE	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7078
p.T2053I	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7078
p.P2052L	ACH-002059	Leukemia	CCLE	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.3056
p.P2052L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation rewiring degron network	0.3056
p.P55S	ACH-002166	Skin Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.P55S	MZ7-mel	skin	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1389
p.P54L	COLO-680N	oesophagus	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1111
p.P54L	EB2	haematopoietic and lymphoid tissue	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1111
p.P54L	NCI-H748	lung	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.1111
p.A2056E	OE33	oesophagus	COSMIC	LTPSRT	DEG_SCF_FBW7_1	2053:2058	Mutation altering degron motif	0.7701
p.L1900P	MFE-319	endometrium	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	1905:1911	Mutation rewiring degron network	0.1944
p.A190D	LOUCY	haematopoietic and lymphoid tissue	COSMIC	VVTPAAS	DEG_SCF_FBW7_1	195:201	Mutation rewiring degron network	0.1944
p.R53L	NCI-H748	lung	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0833
p.R53L	EB2	haematopoietic and lymphoid tissue	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation rewiring degron network	0.0833
p.P66A	MHH-CALL-2	haematopoietic and lymphoid tissue	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	62:69	Mutation altering degron motif	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC16A

UniProt ID: O15027

Entrez ID: 9919

Protein name: Protein transport protein Sec16A (SEC16 homolog A) (p250)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC16A in