DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_FBW7_1

Location: 62:69

E3 ligase: FBXW7

DEGRON score: 0.9954

ASA_SCORE: 86.1875

COIL: 0.96

CONS_SCORE: 0.2358

DSS_SCORE: 0.6013

HELIX: 0.0183

FCONS_SCORE: 0.8945

RIG_SCORE: 0.6197

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A56T	TCGA-DU-6392	LGG	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	0.1667
p.A56T	DO22237	LGG	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.1667
p.D53N	TCGA-EE-A2MT	SKCM	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	0.0833
p.D53N	DO50694	ORCA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.0833
p.D53N	DO38051	SKCM	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.0833
p.A61V	TCGA-HU-A4H8	STAD	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	0.3056
p.A61V	DO47869	STAD	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.3056
p.S70L	TCGA-QB-A6FS	SKCM	TCGA	LQSTPLGS	DEG_SCF_FBW7_1	0.3056
p.S70L	DO48654	SKCM	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.3056
p.P76H	DO222414	BTCA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.1389
p.T68P	DO228799	GACA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.7031
p.T68P	DO229350	LAML	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.7031
p.L67M	DO228976	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.5999
p.S79P	DO228976	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.0556
p.S79P	DO229027	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.0556
p.S79P	ACH-000349	Breast Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	0.0556
p.P54T	DO229026	LICA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.1111
p.P76S	DO222714	MELA	ICGC	LQSTPLGS	DEG_SCF_FBW7_1	0.1389
p.P55A	ACH-000780	Lung Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	0.1389
p.P55A	NCI-H1105	lung	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.1389
p.L71H	ACH-000999	Colon/Colorectal Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	0.2778
p.L71H	SNU-1040	large_intestine	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.2778
p.P70S	ACH-001190	Skin Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	0.3056
p.P70S	SK-MEL-2	skin	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.3056
p.P55S	ACH-002166	Skin Cancer	CCLE	LQSTPLGS	DEG_SCF_FBW7_1	0.1389
p.P55S	MZ7-mel	skin	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.1389
p.P54L	COLO-680N	oesophagus	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.1111
p.P54L	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.1111
p.P54L	NCI-H748	lung	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.1111
p.R53L	NCI-H748	lung	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.0833
p.R53L	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.0833
p.P66A	MHH-CALL-2	haematopoietic_and_lymphoid_tissue	COSMIC	LQSTPLGS	DEG_SCF_FBW7_1	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQSTPLGS

Degron related mutations and impact score

Drug responses associated with SEC16A mutations

All proteins holding degron of LQSTPLGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_FBW7_1	62:69	LQSTPLGS	FBXW7	0.9954	More...