DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_FBW7_1

Location: 195:201

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 83.4

COIL: 0.9671

CONS_SCORE: 0.2657

DSS_SCORE: 0.7941

HELIX: 0.0123

FCONS_SCORE: 1.0135

RIG_SCORE: 0.6421

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S187I	TCGA-86-8073	LUAD	TCGA	VVTPAAS	DEG_SCF_FBW7_1	0.5556
p.S187I	DO23624	LUAD	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.5556
p.A199V	TCGA-BS-A0TJ	UCEC	TCGA	VVTPAAS	DEG_SCF_FBW7_1	0.5825
p.A199V	DO42953	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.5825
p.G194C	TCGA-ER-A19G	SKCM	TCGA	VVTPAAS	DEG_SCF_FBW7_1	0.3056
p.G194C	DO47284	SKCM	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.3056
p.A200V	TCGA-G7-6795	KIRP	TCGA	VVTPAAS	DEG_SCF_FBW7_1	0.5825
p.A200V	DO20851	KIRP	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.5825
p.P205S	TCGA-GN-A26C	SKCM	TCGA	VVTPAAS	DEG_SCF_FBW7_1	0.2222
p.P205S	DO37782	SKCM	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.2222
p.G207R	DO233207	GACA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.1667
p.R210Q	DO233882	GACA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.0833
p.D201E	DO229008	LICA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.6758
p.S203F	DO229177	LMS	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.7222
p.Q210K	DO27883	ORCA	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.0833
p.Y199C	DO42023	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.7087
p.R198C	DO41871	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.8301
p.V200I	DO43907	UCEC	ICGC	VVTPAAS	DEG_SCF_FBW7_1	0.7076
p.P191S	SIDM00523	Small Cell Lung Carcinoma	GDSC	VVTPAAS	DEG_SCF_FBW7_1	0.2222
p.P191S	DMS-53	lung	COSMIC	VVTPAAS	DEG_SCF_FBW7_1	0.2222
p.A195E	ACH-000162	Lymphoma	CCLE	VVTPAAS	DEG_SCF_FBW7_1	0.7701
p.F198Y	ACH-000733	Lung Cancer	CCLE	VVTPAAS	DEG_SCF_FBW7_1	0.7528
p.F198Y	NCI-H1838	lung	COSMIC	VVTPAAS	DEG_SCF_FBW7_1	0.7528
p.A190D	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	VVTPAAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_FBW7_1	195:201	VVTPAAS	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons