DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRSVHSE
Uniprot ID:
O15027
Source protein:
Protein transport protein Sec16A
Source gene:
SEC16A
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1345:1351
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9649
ASA_SCORE:
88.8
COIL:
0.811
CONS_SCORE:
0.306
DSS_SCORE:
0.6272
HELIX:
0.1371
FCONS_SCORE:
0.7417
RIG_SCORE:
0.6291
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1345Q
DO228941
LICA
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.7329
p.R1346H
SIDM01110
Hepatocellular Carcinoma
GDSC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.7133
p.R1346H
SK-HEP-1
liver
COSMIC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.7133
p.S1347N
SIDM01608
Endometrial Carcinoma
GDSC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.7069
p.S1356I
TCGA-FI-A2D5
UCEC
TCGA
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.6389
p.S1356I
DO41331
UCEC
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.6389
p.V1348I
TCGA-AJ-A8CW
UCEC
TCGA
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.5965
p.V1348I
DO52654
MALY
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.5965
p.V1348I
DO52400
UCEC
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.5965
p.E1342K
TCGA-GN-A8LK
SKCM
TCGA
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.25
p.E1342K
DO51259
SKCM
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.25
p.A1354E
DO229024
LICA
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.25
p.R1355W
TCGA-QQ-A8VF
SARC
TCGA
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.2222
p.R1355W
DO220258
SARC
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.2222
p.A1360T
DO233898
GACA
ICGC
RRSVHSE
LIG_APCC_ABBAyCdc20_2
0.0833
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Drug responses associated with SEC16A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of RRSVHSE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15027
Protein transport protein Sec16A
LIG_APCC_ABBAyCdc20_2
1345:1351
RRSVHSE
APC,CDC20,FZR1
0.9649
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