DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: LIG_APCC_ABBAyCdc20_2

Location: 1345:1351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9649

ASA_SCORE: 88.8

COIL: 0.811

CONS_SCORE: 0.306

DSS_SCORE: 0.6272

HELIX: 0.1371

FCONS_SCORE: 0.7417

RIG_SCORE: 0.6291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1348I	TCGA-AJ-A8CW	UCEC	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V1348I	DO52654	MALY	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.5965
p.V1348I	DO52400	UCEC	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.5965
p.S1356I	TCGA-FI-A2D5	UCEC	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S1356I	DO41331	UCEC	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.6389
p.E1342K	TCGA-GN-A8LK	SKCM	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.E1342K	DO51259	SKCM	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1355W	TCGA-QQ-A8VF	SARC	TCGA	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R1355W	DO220258	SARC	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A1360T	DO233898	GACA	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1345Q	DO228941	LICA	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.7329
p.A1354E	DO229024	LICA	ICGC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.R1346H	SIDM01110	Hepatocellular Carcinoma	GDSC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R1346H	SK-HEP-1	liver	COSMIC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.7133
p.S1347N	SIDM01608	Endometrial Carcinoma	GDSC	RRSVHSE	LIG_APCC_ABBAyCdc20_2	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	LIG_APCC_ABBAyCdc20_2	1345:1351	RRSVHSE	APC,CDC20,FZR1	0.9649	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons