DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_FBW7_2

Location: 1905:1911

E3 ligase: FBXW7

DEGRON score: 0.932

ASA_SCORE: 75.7143

COIL: 0.8761

CONS_SCORE: 0.2647

DSS_SCORE: 0.7409

HELIX: 0.076

FCONS_SCORE: 0.9302

RIG_SCORE: 0.614

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1901S	TCGA-A6-6654	COAD	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901S	DO9498	COAD	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1905S	TCGA-AA-3977	COAD	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.6752
p.P1905S	DO8730	COAD	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.6752
p.Q1896H	TCGA-AP-A0LM	UCEC	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.0833
p.Q1896H	DO43306	UCEC	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.0833
p.G1906D	TCGA-B5-A3FC	UCEC	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.6087
p.G1906D	DO41871	UCEC	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.6087
p.H1895N	DO228985	LICA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.0556
p.Q1903K	DO229037	LICA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.2778
p.P1905L	DO219871	SKCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.6471
p.D1897N	DO229268	THCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.1111
p.R1917W	DO229250	THCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.1667
p.P1901L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00971	Breast Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00875	Breast Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00808	Burkitt's Lymphoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM01254	Burkitt's Lymphoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1900L	ACH-000380	Myeloma	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1944
p.P1900L	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.1944
p.K1911E	ACH-000904	Lung Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.7022
p.K1911E	ACH-001362	Lung Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.7022
p.K1911E	NCI-H1770	lung	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.7022
p.S1903F	ACH-000987	Skin Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.2778
p.S1903F	Mewo	skin	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.2778
p.T1898R	ACH-001065	Breast Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1389
p.T1898R	EVSA-T	breast	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.1389
p.T1898K	ACH-001484	Leukemia	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1389
p.T1898K	ACH-001485	Leukemia	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1389
p.T1898M	ACH-001517	Endometrial/Uterine Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1389
p.T1898M	HEC-1	endometrium	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.1389
p.L1900P	MFE-319	endometrium	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPSSE

Degron related mutations and impact score

Drug responses associated with SEC16A mutations

All proteins holding degron of PGTPSSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_FBW7_2	1905:1911	PGTPSSE	FBXW7	0.932	More...