DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_FBW7_2

Location: 1905:1911

E3 ligase: FBXW7

DEGRON score: 0.932

ASA_SCORE: 75.7143

COIL: 0.8761

CONS_SCORE: 0.2647

DSS_SCORE: 0.7409

HELIX: 0.076

FCONS_SCORE: 0.9302

RIG_SCORE: 0.614

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1911E	ACH-000904	Lung Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.7022
p.K1911E	ACH-001362	Lung Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.7022
p.K1911E	NCI-H1770	lung	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.7022
p.P1905S	TCGA-AA-3977	COAD	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.6752
p.P1905S	DO8730	COAD	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.6752
p.P1905L	DO219871	SKCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.6471
p.G1906D	TCGA-B5-A3FC	UCEC	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.6087
p.G1906D	DO41871	UCEC	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.6087
p.Q1903K	DO229037	LICA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.2778
p.S1903F	ACH-000987	Skin Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.2778
p.S1903F	Mewo	skin	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.2778
p.P1901S	TCGA-A6-6654	COAD	TCGA	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901S	DO9498	COAD	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00971	Breast Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00875	Breast Carcinoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM00808	Burkitt's Lymphoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1901L	SIDM01254	Burkitt's Lymphoma	GDSC	PGTPSSE	DEG_SCF_FBW7_2	0.2222
p.P1900L	ACH-000380	Myeloma	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1944
p.P1900L	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.1944
p.L1900P	MFE-319	endometrium	COSMIC	PGTPSSE	DEG_SCF_FBW7_2	0.1944
p.R1917W	DO229250	THCA	ICGC	PGTPSSE	DEG_SCF_FBW7_2	0.1667
p.T1898R	ACH-001065	Breast Cancer	CCLE	PGTPSSE	DEG_SCF_FBW7_2	0.1389

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Drug responses associated with SEC16A mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PGTPSSE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_FBW7_2	1905:1911	PGTPSSE	FBXW7	0.932	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTPSSE

Degron related mutations and impact score

Drug responses associated with SEC16A mutations

All proteins holding degron of PGTPSSE