DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_COP1_1

Location: 442:451

E3 ligase: COP1

DEGRON score: 0.9573

ASA_SCORE: 68.13

COIL: 0.8967

CONS_SCORE: 0.2621

DSS_SCORE: 0.58

HELIX: 0.0625

FCONS_SCORE: 1.0164

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T443K	TCGA-2G-AAGY	TGCT	TCGA	DTASTGVPDA	DEG_COP1_1	0.6195
p.N458I	DO51962	PRAD	ICGC	DTASTGVPDA	DEG_COP1_1	0.1389
p.A451T	ACH-000990	Endometrial/Uterine Cancer	CCLE	DTASTGVPDA	DEG_COP1_1	0.7139
p.P435L	ACH-000999	Colon/Colorectal Cancer	CCLE	DTASTGVPDA	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_COP1_1	442:451	DTASTGVPDA	COP1	0.9573	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons