DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_TRCP1_1

Location: 878:884

E3 ligase: BTRC

DEGRON score: 0.9439

ASA_SCORE: 77.2143

COIL: 0.8924

CONS_SCORE: 0.228

DSS_SCORE: 0.4472

HELIX: 0.0731

FCONS_SCORE: 0.9168

RIG_SCORE: 0.6344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D878N	TCGA-BH-A1FM	BRCA	TCGA	DSGENTS	DEG_SCF_TRCP1_1	0.6932
p.D878N	DO1364	BRCA	ICGC	DSGENTS	DEG_SCF_TRCP1_1	0.6932
p.G880V	TCGA-EE-A2GH	SKCM	TCGA	DSGENTS	DEG_SCF_TRCP1_1	0.7532
p.G880V	DO37643	SKCM	ICGC	DSGENTS	DEG_SCF_TRCP1_1	0.7532
p.G887V	TCGA-EE-A2MD	SKCM	TCGA	DSGENTS	DEG_SCF_TRCP1_1	0.25
p.G887V	DO37851	SKCM	ICGC	DSGENTS	DEG_SCF_TRCP1_1	0.25
p.G876C	TCGA-GN-A26D	SKCM	TCGA	DSGENTS	DEG_SCF_TRCP1_1	0.2778
p.G876C	DO37480	SKCM	ICGC	DSGENTS	DEG_SCF_TRCP1_1	0.2778
p.P868L	DO222908	MELA	ICGC	DSGENTS	DEG_SCF_TRCP1_1	0.0556
p.G876D	SIDM01953	Colorectal Carcinoma	GDSC	DSGENTS	DEG_SCF_TRCP1_1	0.2778
p.G887E	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	DSGENTS	DEG_SCF_TRCP1_1	0.25
p.E877K	ACH-000246	Kidney Cancer	CCLE	DSGENTS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_TRCP1_1	878:884	DSGENTS	BTRC	0.9439	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons