DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_FBW7_2

Location: 2229:2235

E3 ligase: FBXW7

DEGRON score: 0.9859

ASA_SCORE: 80.2714

COIL: 0.9119

CONS_SCORE: 0

DSS_SCORE: 0.7032

HELIX: 0.0477

FCONS_SCORE: 0

RIG_SCORE: 0.6793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2234E	SIDM00477	Esophageal Carcinoma	GDSC	VPTPDAE	DEG_SCF_FBW7_2	0.659
p.A2234E	OE33	oesophagus	COSMIC	VPTPDAE	DEG_SCF_FBW7_2	0.659
p.T2231I	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VPTPDAE	DEG_SCF_FBW7_2	0.8189
p.T2231I	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPDAE	DEG_SCF_FBW7_2	0.8189
p.P2230L	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VPTPDAE	DEG_SCF_FBW7_2	0.6471
p.P2230L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPDAE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_FBW7_2	2229:2235	VPTPDAE	FBXW7	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons