DegronMD

Uniprot ID: O15027

Source protein: Protein transport protein Sec16A

Source gene: SEC16A

Class: DEG_SCF_FBW7_1

Location: 2053:2058

E3 ligase: FBXW7

DEGRON score: 0.9519

ASA_SCORE: 96.3667

COIL: 0.953

CONS_SCORE: 0.2637

DSS_SCORE: 0.6664

HELIX: 0.015

FCONS_SCORE: 0.8974

RIG_SCORE: 0.6532

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2055H	TCGA-2W-A8YY	CESC	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.7694
p.P2055H	TCGA-ER-A19P	SKCM	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.7694
p.P2055H	DO223732	CESC	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.7694
p.P2055H	DO47623	SKCM	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.7694
p.W2068L	TCGA-55-6979	LUAD	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.0556
p.W2068L	DO24110	LUAD	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.0556
p.E2044D	TCGA-AA-3984	COAD	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.0833
p.E2044D	DO9002	COAD	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.0833
p.E2043K	TCGA-BS-A0UV	UCEC	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.0556
p.E2043K	DO42793	UCEC	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.0556
p.E2043K	SIDM02013	Colorectal Carcinoma	GDSC	LTPSRT	DEG_SCF_FBW7_1	0.0556
p.P2066R	TCGA-CN-6019	HNSC	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.1111
p.P2066R	DO14316	HNSC	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.1111
p.K2049Q	TCGA-EY-A1GI	UCEC	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.3333
p.K2049Q	DO41211	UCEC	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.3333
p.A2051T	TCGA-G7-A8LE	KIRP	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.2778
p.A2051T	DO51555	KIRP	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.2778
p.S2056L	TCGA-GN-A266	SKCM	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.7667
p.S2056L	DO37432	SKCM	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.7667
p.F2046C	TCGA-KD-A5QU	SARC	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.F2046C	DO223272	SARC	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.S2062L	TCGA-S5-AA26	BLCA	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.2222
p.S2062L	DO51904	BLCA	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.2222
p.S2062L	SIDM00973	Melanoma	GDSC	LTPSRT	DEG_SCF_FBW7_1	0.2222
p.S2062L	WM793B	skin	COSMIC	LTPSRT	DEG_SCF_FBW7_1	0.2222
p.P2065L	TCGA-W3-AA1R	SKCM	TCGA	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.P2065L	DO51275	SKCM	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.F2046L	DO225032	BRCA	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.E2044Q	DO233952	GACA	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.0833
p.E2044Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LTPSRT	DEG_SCF_FBW7_1	0.0833
p.E2044Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSRT	DEG_SCF_FBW7_1	0.0833
p.D2061E	DO229028	LICA	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.25
p.P2060Q	DO229034	LICA	ICGC	LTPSRT	DEG_SCF_FBW7_1	0.2778
p.P2065S	SIDM01193	Glioma	GDSC	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.P2065S	SIDM01323	Oral Cavity Carcinoma	GDSC	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.P2065S	U-118-MG	central_nervous_system	COSMIC	LTPSRT	DEG_SCF_FBW7_1	0.1389
p.N2048H	ACH-000165	Non-Cancerous	CCLE	LTPSRT	DEG_SCF_FBW7_1	0.1944
p.T2053I	ACH-002059	Leukemia	CCLE	LTPSRT	DEG_SCF_FBW7_1	0.7078
p.T2053I	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSRT	DEG_SCF_FBW7_1	0.7078
p.P2052L	ACH-002059	Leukemia	CCLE	LTPSRT	DEG_SCF_FBW7_1	0.3056
p.P2052L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSRT	DEG_SCF_FBW7_1	0.3056
p.A2056E	OE33	oesophagus	COSMIC	LTPSRT	DEG_SCF_FBW7_1	0.7701

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPSRT

Degron related mutations and impact score

Drug responses associated with SEC16A mutations

All proteins holding degron of LTPSRT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15027	Protein transport protein Sec16A	DEG_SCF_FBW7_1	2053:2058	LTPSRT	FBXW7	0.9519	More...