DegronMD

Uniprot ID: Q9Y466

Source protein: Nuclear receptor subfamily 2 group E member 1

Source gene: NR2E1

Class: DEG_SPOP_SBC_1

Location: 5:9

E3 ligase: SPOP

DEGRON score: 0.7921

ASA_SCORE: 78.26

COIL: 0.8858

CONS_SCORE: 0.6899

DSS_SCORE: 0.5675

HELIX: 0.0996

FCONS_SCORE: 0.9205

RIG_SCORE: 0.6774

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A6S	DO229035	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.7588
p.E7D	DO229031	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.6758
p.G6V	DO229018	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.6421
p.A5V	DO229167	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.5825
p.F2L	DO222884	COCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3611
p.F2V	DO41542	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3611
p.R10H	TCGA-B5-A11E	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.3056
p.R10H	TCGA-BR-8081	STAD	TCGA	AGSTS	DEG_SPOP_SBC_1	0.3056
p.R10H	TCGA-EO-A22R	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.3056
p.R10H	DO38795	STAD	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.R10H	DO41644	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.R10H	DO42713	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.P4Q	DO229088	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.3056
p.K11N	DO223153	ESCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.R3Q	DO49073	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.R3Q	DO43186	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2778
p.E12Q	DO219589	BRCA	ICGC	AGSTS	DEG_SPOP_SBC_1	0.25
p.P13L	DO219477	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2222
p.P17L	DO43186	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.2222
p.R16P	SIDM00679	Cervical Carcinoma	GDSC	AGSTS	DEG_SPOP_SBC_1	0.1389
p.R16P	HT-3	cervix	COSMIC	AGSTS	DEG_SPOP_SBC_1	0.1389
p.V18L	TCGA-BA-A6DA	HNSC	TCGA	AGSTS	DEG_SPOP_SBC_1	0.0833
p.V18L	DO44448	HNSC	ICGC	AGSTS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 23 of 23 entries

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Drug responses associated with NR2E1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AGSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XD8	AN1-type zinc finger protein 4	DEG_SPOP_SBC_1	574:578	AGSTS	SPOP	0.9676	More...
O76080	AN1-type zinc finger protein 5	DEG_SPOP_SBC_1	80:84	AGSTS	SPOP	0.9883	More...
P03372	Estrogen receptor	DEG_SPOP_SBC_1	571:575	AGSTS	SPOP	0.9845	More...
Q96JN0	Ligand-dependent corepressor	DEG_SPOP_SBC_1	93:97	AGSTS	SPOP	0.9806	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	621:625	AGSTS	SPOP	0.9979	More...
Q9Y466	Nuclear receptor subfamily 2 group E member 1	DEG_SPOP_SBC_1	5:9	AGSTS	SPOP	0.7921	More...
O00567	Nucleolar protein 56	DEG_SPOP_SBC_1	526:530	AGSTS	SPOP	0.9464	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	1280:1284	AGSTS	SPOP	0.8593	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_SPOP_SBC_1	469:473	AGSTS	SPOP	0.9917	More...
O15027	Protein transport protein Sec16A	DEG_SPOP_SBC_1	959:963	AGSTS	SPOP	0.9989	More...
Q86X59	Putative uncharacterized protein LINC02875	DEG_SPOP_SBC_1	166:170	AGSTS	SPOP	0.9773	More...
Q9BXF6	Rab11 family-interacting protein 5	DEG_SPOP_SBC_1	38:42	AGSTS	SPOP	0.7413	More...
Q9NW13	RNA-binding protein 28	DEG_SPOP_SBC_1	642:646	AGSTS	SPOP	0.9698	More...
Q14186	Transcription factor Dp-1	DEG_SPOP_SBC_1	350:354	AGSTS	SPOP	0.9899	More...
P15923	Transcription factor E2-alpha	DEG_SPOP_SBC_1	453:457	AGSTS	SPOP	0.9279	More...
Q9Y5Q3	Transcription factor MafB	DEG_SPOP_SBC_1	309:313	AGSTS	SPOP	0.9235	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	778:782	AGSTS	SPOP	0.7948	More...
Q8IYL3	UPF0688 protein C1orf174	DEG_SPOP_SBC_1	33:37	AGSTS	SPOP	0.9615	More...

Showing 1 to 18 of 18 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AGSTS

Degron related mutations and impact score

Drug responses associated with NR2E1 mutations

All proteins holding degron of AGSTS