DegronMD - Q9Y5Q3(MAFB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E299G	TCGA-BR-8589	STAD	TCGA	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.0556
p.E299G	DO47813	STAD	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.0556
p.T47A	TCGA-FD-A6TF	BLCA	TCGA	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.T47A	DO51880	BLCA	ICGC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.S317Y	TCGA-FS-A1ZU	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation blocking phosphorylation signal	0.6667
p.S317Y	DO37723	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation blocking phosphorylation signal	0.6667
p.S304F	TCGA-H4-A2HO	BLCA	TCGA	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation blocking phosphorylation signal	0.6389
p.S304F	DO494	BLCA	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation blocking phosphorylation signal	0.6389
p.P319A	TCGA-OR-A5KB	ACC	TCGA	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.T312P	DO48449	BLCA	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.7031
p.P45L	DO234255	ESAD	ICGC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P45S	DO228377	LICA	ICGC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.Q50K	DO229006	LICA	ICGC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.P319S	DO229177	LMS	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.P319L	DO229177	LMS	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation rewiring degron network	0.1667
p.S317P	DO219881	SKCA	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation blocking phosphorylation signal	0.6667
p.G310D	DO229234	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.6087
p.A52P	SIDM00596	Endometrial Carcinoma	GDSC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.A52P	ACH-001517	Endometrial/Uterine Cancer	CCLE	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.A52P	HEC-1	endometrium	COSMIC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.25
p.S66F	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.S66F	ACH-000912	Lung Cancer	CCLE	VSSTPLST	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.A309V	ACH-000997	Colon/Colorectal Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.5825
p.A309V	ACH-001061	Colon/Colorectal Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.5825
p.A309V	HCT-15	large intestine	COSMIC	AGSTS	DEG_SPOP_SBC_1	309:313	Mutation altering degron motif	0.5825

Kaplan plot for MAFB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAFB

UniProt ID: Q9Y5Q3

Entrez ID: 9935

Protein name: Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAFB in