DegronMD

Uniprot ID: Q9Y5Q3

Source protein: Transcription factor MafB

Source gene: MAFB

Class: DEG_SCF_FBW7_1

Location: 55:62

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 75.375

COIL: 0.9273

CONS_SCORE: 0.481

DSS_SCORE: 0.5637

HELIX: 0.0399

FCONS_SCORE: 1.1137

RIG_SCORE: 0.5821

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T47A	TCGA-FD-A6TF	BLCA	TCGA	VSSTPLST	DEG_SCF_FBW7_1	0.1111
p.T47A	DO51880	BLCA	ICGC	VSSTPLST	DEG_SCF_FBW7_1	0.1111
p.P45L	DO234255	ESAD	ICGC	VSSTPLST	DEG_SCF_FBW7_1	0.0556
p.P45S	DO228377	LICA	ICGC	VSSTPLST	DEG_SCF_FBW7_1	0.0556
p.Q50K	DO229006	LICA	ICGC	VSSTPLST	DEG_SCF_FBW7_1	0.1944
p.A52P	SIDM00596	Endometrial Carcinoma	GDSC	VSSTPLST	DEG_SCF_FBW7_1	0.25
p.A52P	ACH-001517	Endometrial/Uterine Cancer	CCLE	VSSTPLST	DEG_SCF_FBW7_1	0.25
p.A52P	HEC-1	endometrium	COSMIC	VSSTPLST	DEG_SCF_FBW7_1	0.25
p.S66F	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VSSTPLST	DEG_SCF_FBW7_1	0.2222
p.S66F	ACH-000912	Lung Cancer	CCLE	VSSTPLST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5Q3	Transcription factor MafB	DEG_SCF_FBW7_1	55:62	VSSTPLST	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons