DegronMD - Q96JN0(LCOR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q49E	TCGA-17-Z026	LUAD	TCGA	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.P38A	TCGA-44-A47G	LUAD	TCGA	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6392
p.P38A	DO23681	LUAD	ICGC	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6392
p.S101Y	TCGA-93-8067	LUAD	TCGA	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.2222
p.S101Y	DO25113	LUAD	ICGC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.2222
p.D84H	TCGA-NC-A5HG	LUSC	TCGA	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0833
p.D84H	TCGA-V1-A9OQ	PRAD	TCGA	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0833
p.D84H	DO45448	LUSC	ICGC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0833
p.D84H	DO219383	PRAD	ICGC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0833
p.P38S	DO233634	GACA	ICGC	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.6752
p.G103V	DO229028	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1667
p.P91S	DO220899	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.2778
p.A93T	DO229253	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.7139
p.T44M	SIDM00461	Acute Myeloid Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.T44M	SIDM00217	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.T44M	ACH-000065	Leukemia	CCLE	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.T44M	ACH-000999	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.T44M	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.T44M	SNU-1040	large intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	38:42	Mutation blocking phosphorylation signal	0.7222
p.G94S	SIDM00845	Burkitt's Lymphoma	GDSC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.5882
p.G94S	ACH-000786	Lymphoma	CCLE	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.5882
p.V94M	EFO-27	ovary	COSMIC	AGSTS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.7208

Kaplan plot for LCOR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LCOR

UniProt ID: Q96JN0

Entrez ID: 84458

Protein name: Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LCOR in