DegronMD - O00567(NOP56)

FUNCTION: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. {ECO:0000269|PubMed:12777385, ECO:0000269|PubMed:15574333}.

GO - Biological processes (BP): rRNA processing [GO:0006364]

GO - Molecular function (MF): cadherin binding [GO:0045296]; histone methyltransferase binding [GO:1990226]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]

GO - Cellular component (CC): box C/D RNP complex [GO:0031428]; cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; pre-snoRNP complex [GO:0070761]; small-subunit processome [GO:0032040]; sno(s)RNA-containing ribonucleoprotein complex [GO:0005732]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
PRKNLDVMK	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Nucleolar protein 56	414:422	More..
AGSTS	DEG_SPOP_SBC_1	SPOP	Nucleolar protein 56	526:530	More..

Showing 1 to 2 of 2 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R415Q	TCGA-19-5956	GBM	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.7329
p.R415Q	DO13863	GBM	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.7329
p.A526T	DO229054	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7139
p.A526T	ACH-001396	Metastasis	CCLE	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7139
p.N417I	TCGA-OR-A5LB	ACC	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6169
p.K422R	SIDM00999	Bladder Carcinoma	GDSC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6126
p.K422R	ACH-000973	Bladder Cancer	CCLE	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6126
p.K422R	639-V	urinary tract	COSMIC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6126
p.S520G	DO222875	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6111
p.T538A	DO23188	LINC	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.5556
p.K535N	ACH-000836	Head and Neck Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation substituting flanking lysine	0.3056
p.P532H	TCGA-AG-3906	READ	TCGA	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P532H	TCGA-DA-A1I7	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P532H	DO36491	READ	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P532H	DO37951	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.M425V	DO231096	LUSC	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.25
p.L522F	TCGA-EB-A4IS	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.L522F	DO47281	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.E409Q	TCGA-55-7281	LUAD	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.1944
p.E409Q	DO25985	LUAD	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 24 entries

Previous1 2Next

No resistance data available for this Degron.

Kaplan plot for NOP56 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOP56

UniProt ID: O00567

Entrez ID: 10528

Protein name: Nucleolar protein 56 (Nucleolar protein 5A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No resistance data available for this Degron.

Kaplan plot for NOP56 in