DegronMD - O00567(NOP56)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R415Q	TCGA-19-5956	GBM	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.7329
p.R415Q	DO13863	GBM	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.7329
p.E409Q	TCGA-55-7281	LUAD	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.1944
p.E409Q	DO25985	LUAD	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.1944
p.P532H	TCGA-AG-3906	READ	TCGA	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P532H	TCGA-DA-A1I7	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P532H	DO36491	READ	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.P532H	DO37951	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2778
p.A431V	TCGA-AX-A1CE	UCEC	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.0833
p.A431V	TCGA-L5-A8NM	ESCA	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.0833
p.A431V	DO42280	UCEC	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.0833
p.L522F	TCGA-EB-A4IS	SKCM	TCGA	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.L522F	DO47281	SKCM	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.2222
p.N417I	TCGA-OR-A5LB	ACC	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6169
p.A526T	DO229054	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7139
p.A526T	ACH-001396	Metastasis	CCLE	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation altering degron motif	0.7139
p.T538A	DO23188	LINC	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.5556
p.M425V	DO231096	LUSC	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation rewiring degron network	0.25
p.S520G	DO222875	MELA	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation blocking phosphorylation signal	0.6111
p.P539S	DO49202	PACA	ICGC	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation rewiring degron network	0.0833
p.K422R	SIDM00999	Bladder Carcinoma	GDSC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6126
p.K422R	ACH-000973	Bladder Cancer	CCLE	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6126
p.K422R	639-V	urinary tract	COSMIC	PRKNLDVMK	DEG_APCC_DBOX_1	414:422	Mutation altering degron motif	0.6126
p.K535N	ACH-000836	Head and Neck Cancer	CCLE	AGSTS	DEG_SPOP_SBC_1	526:530	Mutation substituting flanking lysine	0.3056

Kaplan plot for NOP56 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOP56

UniProt ID: O00567

Entrez ID: 10528

Protein name: Nucleolar protein 56 (Nucleolar protein 5A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOP56 in