DegronMD

Uniprot ID: O00567

Source protein: Nucleolar protein 56

Source gene: NOP56

Class: DEG_APCC_DBOX_1

Location: 414:422

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9728

ASA_SCORE: 89.3111

COIL: 0.4996

CONS_SCORE: 0.492

DSS_SCORE: 0.3642

HELIX: 0.4877

FCONS_SCORE: 1.2

RIG_SCORE: 0.795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R415Q	TCGA-19-5956	GBM	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	0.7329
p.R415Q	DO13863	GBM	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	0.7329
p.E409Q	TCGA-55-7281	LUAD	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	0.1944
p.E409Q	DO25985	LUAD	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	0.1944
p.A431V	TCGA-AX-A1CE	UCEC	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	0.0833
p.A431V	TCGA-L5-A8NM	ESCA	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	0.0833
p.A431V	DO42280	UCEC	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	0.0833
p.N417I	TCGA-OR-A5LB	ACC	TCGA	PRKNLDVMK	DEG_APCC_DBOX_1	0.6169
p.M425V	DO231096	LUSC	ICGC	PRKNLDVMK	DEG_APCC_DBOX_1	0.25
p.K422R	SIDM00999	Bladder Carcinoma	GDSC	PRKNLDVMK	DEG_APCC_DBOX_1	0.6126
p.K422R	ACH-000973	Bladder Cancer	CCLE	PRKNLDVMK	DEG_APCC_DBOX_1	0.6126
p.K422R	639-V	urinary_tract	COSMIC	PRKNLDVMK	DEG_APCC_DBOX_1	0.6126

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00567	Nucleolar protein 56	DEG_APCC_DBOX_1	414:422	PRKNLDVMK	APC,CDC20,FZR1	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons