DegronMD - O76080(ZFAND5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A80V	TCGA-19-5956	GBM	TCGA	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation altering degron motif	0.5825
p.A80V	DO13863	GBM	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation altering degron motif	0.5825
p.A195S	TCGA-24-1431	OV	TCGA	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.2222
p.A195S	DO32307	OV	ICGC	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.2222
p.S105I	TCGA-A5-A1OF	UCEC	TCGA	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.1389
p.S105I	DO42568	UCEC	ICGC	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.1389
p.A196V	TCGA-A6-A565	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.A196V	DO44090	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.K86Q	TCGA-DJ-A13U	THCA	TCGA	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation blocking ubiquitination signal	0.7222
p.K86Q	DO40257	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation blocking ubiquitination signal	0.7222
p.V206G	TCGA-EJ-5496	PRAD	TCGA	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.V206G	DO36266	PRAD	ICGC	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.N75D	TCGA-EO-A3KX	UCEC	TCGA	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.1944
p.N75D	DO219774	UCEC	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.1944
p.K111N	TCGA-F5-6814	READ	TCGA	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.3056
p.K111N	DO36556	READ	ICGC	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.3056
p.S120L	TCGA-GM-A2DO	BRCA	TCGA	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.2778
p.S120L	DO2037	BRCA	ICGC	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.2778
p.S128I	TCGA-IB-7651	PAAD	TCGA	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation blocking phosphorylation signal	0.5
p.S128I	DO46657	PAAD	ICGC	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation blocking phosphorylation signal	0.5
p.A196E	TCGA-QF-A5YS	UCEC	TCGA	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.A196E	DO52426	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.S82R	DO228974	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation altering degron motif	0.7427
p.T71N	DO229019	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.0833
p.N75K	DO229031	LICA	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.1944
p.P127H	DO229045	LICA	ICGC	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation rewiring degron network	0.0833
p.D70N	DO231204	LUSC	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.0556
p.N74S	DO229253	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.1667
p.A93V	DO229272	THCA	ICGC	AGSTS	DEG_SPOP_SBC_1	80:84	Mutation rewiring degron network	0.0833
p.V206A	SIDM01463	Endometrial Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.V206A	ACH-000397	Endometrial/Uterine Cancer	CCLE	RKENP	DEG_APCC_KENBOX_2	199:203	Mutation rewiring degron network	0.25
p.T114I	ACH-001322	Sarcoma	CCLE	ITTPKTE	DEG_SCF_FBW7_2	112:118	Mutation altering degron motif	0.7078

Kaplan plot for ZFAND5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFAND5

UniProt ID: O76080

Entrez ID: 7763

Protein name: AN1-type zinc finger protein 5 (Zinc finger A20 domain-containing protein 2) (Zinc finger protein 216)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFAND5 in