DegronMD

Uniprot ID: O76080

Source protein: AN1-type zinc finger protein 5

Source gene: ZFAND5

Class: DEG_APCC_KENBOX_2

Location: 199:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5072

ASA_SCORE: 86.04

COIL: 0.3912

CONS_SCORE: 0.743

DSS_SCORE: 0.2301

HELIX: 0.5964

FCONS_SCORE: 1.1348

RIG_SCORE: 0.797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A195S	TCGA-24-1431	OV	TCGA	RKENP	DEG_APCC_KENBOX_2	0.2222
p.A195S	DO32307	OV	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2222
p.A196V	TCGA-A6-A565	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.25
p.A196V	DO44090	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.25
p.V206G	TCGA-EJ-5496	PRAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.25
p.V206G	DO36266	PRAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.25
p.A196E	TCGA-QF-A5YS	UCEC	TCGA	RKENP	DEG_APCC_KENBOX_2	0.25
p.A196E	DO52426	UCEC	ICGC	RKENP	DEG_APCC_KENBOX_2	0.25
p.V206A	SIDM01463	Endometrial Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	0.25
p.V206A	ACH-000397	Endometrial/Uterine Cancer	CCLE	RKENP	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76080	AN1-type zinc finger protein 5	DEG_APCC_KENBOX_2	199:203	RKENP	APC,CDC20,FZR1	0.5072	More...
Q99708	DNA endonuclease RBBP8	DEG_APCC_KENBOX_2	178:182	RKENP	APC,CDC20,FZR1	0.8804	More...
Q9C040	Tripartite motif-containing protein 2	DEG_APCC_KENBOX_2	463:467	RKENP	APC,CDC20,FZR1	0.6409	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_APCC_KENBOX_2	809:813	RKENP	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons