DegronMD - Q9P1Y6(PHRF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I818M	TCGA-05-4382	LUAD	TCGA	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation blocking phosphorylation signal	0.6389
p.G427V	TCGA-3B-A9I1	SARC	TCGA	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.2222
p.L433M	TCGA-A3-A6NL	KIRC	TCGA	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.5999
p.D804N	TCGA-AA-3984	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.1944
p.A1522T	TCGA-AP-A0LM	UCEC	TCGA	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.25
p.A1522T	TCGA-SW-A7EA	STAD	TCGA	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.25
p.S38N	TCGA-AX-A1CE	UCEC	TCGA	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.25
p.S1105N	TCGA-B5-A3FA	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1944
p.S813L	TCGA-BA-4077	HNSC	TCGA	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7667
p.R1091L	TCGA-BA-6869	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1944
p.D44N	TCGA-BK-A6W3	UCEC	TCGA	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation altering degron motif	0.5821
p.K822E	TCGA-BR-8487	STAD	TCGA	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.0833
p.R1086G	TCGA-BS-A0UV	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.0556
p.D803G	TCGA-CK-4951	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.1667
p.S510W	TCGA-CN-6013	HNSC	TCGA	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.1944
p.L433V	TCGA-CX-7219	HNSC	TCGA	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.5654
p.D41E	TCGA-D1-A1NZ	UCEC	TCGA	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation altering degron motif	0.6758
p.V249G	TCGA-DD-AAEH	LIHC	TCGA	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1111
p.R1091W	TCGA-EI-6882	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1944
p.P1519T	TCGA-ER-A19T	SKCM	TCGA	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.1667
p.S250F	TCGA-ER-A2NC	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1389
p.S250F	SIDM00938	Breast Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1389
p.S250F	ACH-000902	Breast Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1389
p.S250F	CAL-148	breast	COSMIC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1389
p.G53V	TCGA-F4-6856	COAD	TCGA	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1389
p.S430C	TCGA-FU-A3HY	CESC	TCGA	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.3056
p.P1095H	TCGA-LA-A446	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.75
p.L509Q	TCGA-MQ-A4LJ	MESO	TCGA	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.2222
p.S432F	TCGA-MV-A51V	BLCA	TCGA	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.6871
p.G506D	TCGA-SS-A7HO	COAD	TCGA	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.3056
p.A429D	TCGA-UD-AAC5	MESO	TCGA	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.2778
p.S431F	DO474	BLCA	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.7982
p.S429C	DO6284	CESC	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.2778
p.P1518S	DO7442	CLLE	ICGC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.1389
p.G52V	DO9114	COAD	ICGC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1667
p.D803N	DO9002	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.1667
p.D802G	DO10582	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.1389
p.G505D	DO223705	COAD	ICGC	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation altering degron motif	0.7198
p.R1090Q	DO234150	ESAD	ICGC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1667
p.L814H	DO233884	GACA	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation blocking phosphorylation signal	0.75
p.E55K	DO233823	GACA	ICGC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.0833
p.L432V	DO14910	HNSC	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.6765
p.S509W	DO15975	HNSC	ICGC	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.2222
p.S812L	DO15647	HNSC	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7667
p.R1090L	DO14250	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1667
p.L432M	DO50458	KIRC	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.711
p.E809G	DO232025	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7199
p.V248G	DO52272	LIHC	ICGC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0833
p.I817M	DO24900	LUAD	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.2222
p.P1529L	DO231072	LUSC	ICGC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.7582
p.P1094H	DO45450	LUSC	ICGC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.2778
p.A253D	DO232224	PBCA	ICGC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2222
p.R1090W	DO36531	READ	ICGC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1667
p.G426V	DO219941	SARC	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1944
p.P441L	DO229459	SKCA	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1944
p.S249F	DO47318	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1111
p.S249F	CAL-148	breast	COSMIC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1111
p.P1518T	DO51251	SKCM	ICGC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.1389
p.D54G	DO38404	STAD	ICGC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1111
p.A1521T	DO51749	STAD	ICGC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.2222
p.A1521T	DO43306	UCEC	ICGC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.2222
p.K821E	DO47867	STAD	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation substituting flanking lysine	0.2222
p.L514P	DO229229	THCA	ICGC	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.0833
p.D40N	DO50076	UCEC	ICGC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.3056
p.S34N	DO42280	UCEC	ICGC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1389
p.S1104N	DO52402	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.2222
p.D40E	DO41536	UCEC	ICGC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.3056
p.A424V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1389
p.A424V	ACH-000995	Leukemia	CCLE	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1389
p.A424V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1389
p.V36M	SIDM00370	T-Lymphoblastic Leukemia	GDSC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1944
p.V36M	ACH-000197	Leukemia	CCLE	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1944
p.V36M	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1944
p.A267G	SIDM01164	Glioma	GDSC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.A267G	ACH-000883	Brain Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.A267G	SW1783	central nervous system	COSMIC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1667
p.R423K	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1111
p.R423K	ACH-002220	Lymphoma	CCLE	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1111
p.R423K	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1111
p.L816I	SIDM01052	Ovarian Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.25
p.L816I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.25
p.G1097D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.6087
p.G1097D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.6087
p.S1099C	SIDM00870	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.S1099C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.T259I	SIDM00153	T-Lymphoblastic Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.7078
p.T259I	ACH-000964	Leukemia	CCLE	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.7078
p.G268C	SIDM01397	Melanoma	GDSC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1389
p.G268C	ACH-000765	Skin Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1389
p.G43R	SIDM01343	Gastric Carcinoma	GDSC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation altering degron motif	0.7568
p.G43R	ACH-000764	Gastric Cancer	CCLE	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation altering degron motif	0.7568
p.L815I	ACH-000308	Ovarian Cancer	CCLE	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.2778
p.L815I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.2778
p.G40V	ACH-000512	Myeloma	CCLE	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.3056
p.S1098C	ACH-000725	Breast Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.S1098C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.E500K	ACH-000931	Skin Cancer	CCLE	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation altering degron motif	0.591
p.G1096D	ACH-001127	Leukemia	CCLE	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7198
p.G1096D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7198
p.K1107N	ACH-001513	Cervical Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation rewiring degron network	0.1389
p.V256M	ACH-002026	Endometrial/Uterine Cancer	CCLE	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.3056
p.P488S	ACH-002349	Non-Cancerous	CCLE	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.1111
p.V32M	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.0833
p.A1524P	HCC2998	large intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation rewiring degron network	0.3056
p.A1526P	HCC2998	large intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.7503
p.R422K	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.0833
p.S1097C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.A263G	SW1783	central nervous system	COSMIC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.A1527P	HCC2998	large intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.7503
p.A423V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation rewiring degron network	0.1111
p.G1093D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.6944
p.M515R	SK-GT-2	stomach	COSMIC	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.0556
p.L814I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation blocking phosphorylation signal	0.75
p.M513R	SK-GT-2	stomach	COSMIC	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation rewiring degron network	0.1111
p.G1095D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.75
p.L812I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7174
p.S823G	Hep_3B2_1-7	NS	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation substituting flanking lysine	0.1667
p.V35M	TALL-1	haematopoietic and lymphoid tissue	COSMIC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation rewiring degron network	0.1667
p.S1095C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.75
p.A266G	SW1783	central nervous system	COSMIC	VPTTS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1944
p.R822Q	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation rewiring degron network	0.0833
p.A1528P	HCC2998	large intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.6392

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHRF1

UniProt ID: Q9P1Y6

Entrez ID: 57661

Protein name: PHD and RING finger domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHRF1 in