DegronMD - Q9P1Y6(PHRF1)

GO - Biological processes (BP): mRNA processing [GO:0006397]; transcription by RNA polymerase II [GO:0006366]

GO - Molecular function (MF): metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]

GO - Cellular component (CC): membrane [GO:0016020]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
RKENP	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	PHD and RING finger domain-containing protein 1	809:813	More..
DLEEEPVPDL	DEG_COP1_1	COP1	PHD and RING finger domain-containing protein 1	496:505	More..
LTPASE	DEG_SCF_FBW7_2	FBXW7	PHD and RING finger domain-containing protein 1	1525:1530	More..
DSGDDS	DEG_SCF_TRCP1_1	BTRC	PHD and RING finger domain-containing protein 1	41:46	More..
VPTTS	DEG_SPOP_SBC_1	SPOP	PHD and RING finger domain-containing protein 1	257:261	More..
PGSSS	DEG_SPOP_SBC_1	SPOP	PHD and RING finger domain-containing protein 1	1096:1100	More..
LSLFGD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	PHD and RING finger domain-containing protein 1	431:436	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S431F	DO474	BLCA	ICGC	LSLFGD	LIG_APCC_ABBA_1	431:436	Mutation altering degron motif	0.7982
p.S813L	TCGA-BA-4077	HNSC	TCGA	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7667
p.S812L	DO15647	HNSC	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7667
p.P1529L	DO231072	LUSC	ICGC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.7582
p.G43R	SIDM01343	Gastric Carcinoma	GDSC	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation altering degron motif	0.7568
p.G43R	ACH-000764	Gastric Cancer	CCLE	DSGDDS	DEG_SCF_TRCP1_1	41:46	Mutation altering degron motif	0.7568
p.S1099C	SIDM00870	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.S1099C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.S1098C	ACH-000725	Breast Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.S1098C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.S1097C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation altering degron motif	0.7541
p.A1526P	HCC2998	large intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.7503
p.A1527P	HCC2998	large intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	1525:1530	Mutation altering degron motif	0.7503
p.P1095H	TCGA-LA-A446	LUSC	TCGA	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.75
p.L814H	DO233884	GACA	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation blocking phosphorylation signal	0.75
p.L814I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation blocking phosphorylation signal	0.75
p.G1095D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.75
p.S1095C	HCC202	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	1096:1100	Mutation blocking phosphorylation signal	0.75
p.E809G	DO232025	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	809:813	Mutation altering degron motif	0.7199
p.G505D	DO223705	COAD	ICGC	DLEEEPVPDL	DEG_COP1_1	496:505	Mutation altering degron motif	0.7198

Showing 1 to 20 of 122 entries

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Kaplan plot for PHRF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHRF1

UniProt ID: Q9P1Y6

Entrez ID: 57661

Protein name: PHD and RING finger domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHRF1 in