DegronMD

Uniprot ID: Q9P1Y6

Source protein: PHD and RING finger domain-containing protein 1

Source gene: PHRF1

Class: DEG_SCF_FBW7_2

Location: 1525:1530

E3 ligase: FBXW7

DEGRON score: 0.9514

ASA_SCORE: 78.7333

COIL: 0.8967

CONS_SCORE: 0.3102

DSS_SCORE: 0.5015

HELIX: 0.0563

FCONS_SCORE: 0.9874

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1522T	TCGA-AP-A0LM	UCEC	TCGA	LTPASE	DEG_SCF_FBW7_2	0.25
p.A1522T	TCGA-SW-A7EA	STAD	TCGA	LTPASE	DEG_SCF_FBW7_2	0.25
p.P1519T	TCGA-ER-A19T	SKCM	TCGA	LTPASE	DEG_SCF_FBW7_2	0.1667
p.P1518S	DO7442	CLLE	ICGC	LTPASE	DEG_SCF_FBW7_2	0.1389
p.P1529L	DO231072	LUSC	ICGC	LTPASE	DEG_SCF_FBW7_2	0.7582
p.P1518T	DO51251	SKCM	ICGC	LTPASE	DEG_SCF_FBW7_2	0.1389
p.A1521T	DO51749	STAD	ICGC	LTPASE	DEG_SCF_FBW7_2	0.2222
p.A1521T	DO43306	UCEC	ICGC	LTPASE	DEG_SCF_FBW7_2	0.2222
p.A1524P	HCC2998	large_intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	0.3056
p.A1526P	HCC2998	large_intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	0.7503
p.A1527P	HCC2998	large_intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	0.7503
p.A1528P	HCC2998	large_intestine	COSMIC	LTPASE	DEG_SCF_FBW7_2	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_SCF_FBW7_2	1525:1530	LTPASE	FBXW7	0.9514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons