DegronMD

Uniprot ID: Q9P1Y6

Source protein: PHD and RING finger domain-containing protein 1

Source gene: PHRF1

Class: DEG_COP1_1

Location: 496:505

E3 ligase: COP1

DEGRON score: 0.9777

ASA_SCORE: 98.15

COIL: 0.9123

CONS_SCORE: 0.4706

DSS_SCORE: 0.4729

HELIX: 0.0425

FCONS_SCORE: 1.1056

RIG_SCORE: 0.7551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S510W	TCGA-CN-6013	HNSC	TCGA	DLEEEPVPDL	DEG_COP1_1	0.1944
p.L509Q	TCGA-MQ-A4LJ	MESO	TCGA	DLEEEPVPDL	DEG_COP1_1	0.2222
p.G506D	TCGA-SS-A7HO	COAD	TCGA	DLEEEPVPDL	DEG_COP1_1	0.3056
p.G505D	DO223705	COAD	ICGC	DLEEEPVPDL	DEG_COP1_1	0.7198
p.S509W	DO15975	HNSC	ICGC	DLEEEPVPDL	DEG_COP1_1	0.2222
p.L514P	DO229229	THCA	ICGC	DLEEEPVPDL	DEG_COP1_1	0.0833
p.E500K	ACH-000931	Skin Cancer	CCLE	DLEEEPVPDL	DEG_COP1_1	0.591
p.P488S	ACH-002349	Non-Cancerous	CCLE	DLEEEPVPDL	DEG_COP1_1	0.1111
p.M515R	SK-GT-2	stomach	COSMIC	DLEEEPVPDL	DEG_COP1_1	0.0556
p.M513R	SK-GT-2	stomach	COSMIC	DLEEEPVPDL	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_COP1_1	496:505	DLEEEPVPDL	COP1	0.9777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons