DegronMD

Uniprot ID: Q9P1Y6

Source protein: PHD and RING finger domain-containing protein 1

Source gene: PHRF1

Class: LIG_APCC_ABBA_1

Location: 431:436

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7746

ASA_SCORE: 59.1833

COIL: 0.6748

CONS_SCORE: 0.6335

DSS_SCORE: 0.2042

HELIX: 0.163

FCONS_SCORE: 1.3697

RIG_SCORE: 0.7373

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S431F	DO474	BLCA	ICGC	LSLFGD	LIG_APCC_ABBA_1	0.7982
p.L432M	DO50458	KIRC	ICGC	LSLFGD	LIG_APCC_ABBA_1	0.711
p.S432F	TCGA-MV-A51V	BLCA	TCGA	LSLFGD	LIG_APCC_ABBA_1	0.6871
p.L432V	DO14910	HNSC	ICGC	LSLFGD	LIG_APCC_ABBA_1	0.6765
p.L433M	TCGA-A3-A6NL	KIRC	TCGA	LSLFGD	LIG_APCC_ABBA_1	0.5999
p.L433V	TCGA-CX-7219	HNSC	TCGA	LSLFGD	LIG_APCC_ABBA_1	0.5654
p.S430C	TCGA-FU-A3HY	CESC	TCGA	LSLFGD	LIG_APCC_ABBA_1	0.3056
p.A429D	TCGA-UD-AAC5	MESO	TCGA	LSLFGD	LIG_APCC_ABBA_1	0.2778
p.S429C	DO6284	CESC	ICGC	LSLFGD	LIG_APCC_ABBA_1	0.2778
p.G427V	TCGA-3B-A9I1	SARC	TCGA	LSLFGD	LIG_APCC_ABBA_1	0.2222
p.G426V	DO219941	SARC	ICGC	LSLFGD	LIG_APCC_ABBA_1	0.1944
p.P441L	DO229459	SKCA	ICGC	LSLFGD	LIG_APCC_ABBA_1	0.1944
p.A424V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LSLFGD	LIG_APCC_ABBA_1	0.1389
p.A424V	ACH-000995	Leukemia	CCLE	LSLFGD	LIG_APCC_ABBA_1	0.1389
p.A424V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.1389
p.R423K	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	0.1111
p.R423K	ACH-002220	Lymphoma	CCLE	LSLFGD	LIG_APCC_ABBA_1	0.1111
p.R423K	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.1111
p.A423V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.1111
p.R422K	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9Z9	Lamin tail domain-containing protein 1	LIG_APCC_ABBA_1	107:112	LSLFGD	APC,CDC20,FZR1	0.9557	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	LIG_APCC_ABBA_1	431:436	LSLFGD	APC,CDC20,FZR1	0.7746	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons