DegronMD - Q8N9Z9(LMNTD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S102R	SIDM00683	Prostate Carcinoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1944
p.S102R	LNCaP-Clone-FGC	prostate	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1944
p.F108L	SIDM00332	Breast Carcinoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.6981
p.F108L	MFM-223	breast	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.6981
p.E116K	SIDM01018	Hodgkin's Lymphoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2222
p.E116K	KM-H2	haematopoietic and lymphoid tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2222
p.D33E	SIDM01617	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.D112E	MFM-223	breast	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.5647
p.S34C	MFM-223	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.3056
p.N101Y	DMS-53	lung	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1667
p.L115I	HCC2998	large intestine	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation substituting flanking lysine	0.3611
p.L37F	MFM-223	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.6981
p.F110C	NCI-H2110	lung	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation altering degron motif	0.7108
p.D49E	MFM-223	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.0556
p.E32K	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.K114N	HT-115	large intestine	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778
p.F47C	NCI-H2110	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1111
p.S102P	PF-382	haematopoietic and lymphoid tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.1944
p.S114P	SAT	upper aerodigestive tract	COSMIC	LSLFGD	LIG_APCC_ABBA_1	107:112	Mutation rewiring degron network	0.2778

Kaplan plot for LMNTD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMNTD1

UniProt ID: Q8N9Z9

Entrez ID: 160492

Protein name: Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMNTD1 in