DegronMD

Uniprot ID: Q8N9Z9

Source protein: Lamin tail domain-containing protein 1

Source gene: LMNTD1

Class: LIG_APCC_ABBA_1

Location: 107:112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9557

ASA_SCORE: 56.7333

COIL: 0.4262

CONS_SCORE: 0.5511

DSS_SCORE: 0.2122

HELIX: 0.5115

FCONS_SCORE: 1.4173

RIG_SCORE: 0.8106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S102R	SIDM00683	Prostate Carcinoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	0.1944
p.S102R	LNCaP-Clone-FGC	prostate	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.1944
p.F108L	SIDM00332	Breast Carcinoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	0.6981
p.F108L	MFM-223	breast	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.6981
p.E116K	SIDM01018	Hodgkin's Lymphoma	GDSC	LSLFGD	LIG_APCC_ABBA_1	0.2222
p.E116K	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.2222
p.D112E	MFM-223	breast	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.5647
p.N101Y	DMS-53	lung	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.1667
p.L115I	HCC2998	large_intestine	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.3611
p.F110C	NCI-H2110	lung	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.7108
p.K114N	HT-115	large_intestine	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.2778
p.S102P	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.1944
p.S114P	SAT	upper_aerodigestive_tract	COSMIC	LSLFGD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P1Y6	PHD and RING finger domain-containing protein 1	LIG_APCC_ABBA_1	431:436	LSLFGD	APC,CDC20,FZR1	0.7746	More...
Q8N9Z9	Lamin tail domain-containing protein 1	LIG_APCC_ABBA_1	107:112	LSLFGD	APC,CDC20,FZR1	0.9557	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons