DegronMD

Uniprot ID: Q9P1Y6

Source protein: PHD and RING finger domain-containing protein 1

Source gene: PHRF1

Class: DEG_APCC_KENBOX_2

Location: 809:813

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 122.8

COIL: 0.855

CONS_SCORE: 0.3734

DSS_SCORE: 0.6494

HELIX: 0.1278

FCONS_SCORE: 1.0878

RIG_SCORE: 0.667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I818M	TCGA-05-4382	LUAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.6389
p.D804N	TCGA-AA-3984	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.1944
p.S813L	TCGA-BA-4077	HNSC	TCGA	RKENP	DEG_APCC_KENBOX_2	0.7667
p.K822E	TCGA-BR-8487	STAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.0833
p.D803G	TCGA-CK-4951	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.1667
p.D803N	DO9002	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.1667
p.D802G	DO10582	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.1389
p.L814H	DO233884	GACA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.75
p.S812L	DO15647	HNSC	ICGC	RKENP	DEG_APCC_KENBOX_2	0.7667
p.E809G	DO232025	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.7199
p.I817M	DO24900	LUAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2222
p.K821E	DO47867	STAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2222
p.L816I	SIDM01052	Ovarian Carcinoma	GDSC	RKENP	DEG_APCC_KENBOX_2	0.25
p.L816I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.25
p.L815I	ACH-000308	Ovarian Cancer	CCLE	RKENP	DEG_APCC_KENBOX_2	0.2778
p.L815I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.2778
p.L814I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.75
p.L812I	EFO-21	ovary	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.7174
p.S823G	Hep_3B2_1-7	NS	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.1667
p.R822Q	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	RKENP	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76080	AN1-type zinc finger protein 5	DEG_APCC_KENBOX_2	199:203	RKENP	APC,CDC20,FZR1	0.5072	More...
Q99708	DNA endonuclease RBBP8	DEG_APCC_KENBOX_2	178:182	RKENP	APC,CDC20,FZR1	0.8804	More...
Q9C040	Tripartite motif-containing protein 2	DEG_APCC_KENBOX_2	463:467	RKENP	APC,CDC20,FZR1	0.6409	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_APCC_KENBOX_2	809:813	RKENP	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons