DegronMD

Uniprot ID: Q99708

Source protein: DNA endonuclease RBBP8

Source gene: RBBP8

Class: DEG_APCC_KENBOX_2

Location: 178:182

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8804

ASA_SCORE: 121.78

COIL: 0.8494

CONS_SCORE: 0.4966

DSS_SCORE: 0.4033

HELIX: 0.11

FCONS_SCORE: 1.0548

RIG_SCORE: 0.7057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y186C	TCGA-AA-3977	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	0.2222
p.Y186C	DO8730	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	0.2222
p.R175L	DO228986	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.25
p.R177L	DO229041	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76080	AN1-type zinc finger protein 5	DEG_APCC_KENBOX_2	199:203	RKENP	APC,CDC20,FZR1	0.5072	More...
Q99708	DNA endonuclease RBBP8	DEG_APCC_KENBOX_2	178:182	RKENP	APC,CDC20,FZR1	0.8804	More...
Q9C040	Tripartite motif-containing protein 2	DEG_APCC_KENBOX_2	463:467	RKENP	APC,CDC20,FZR1	0.6409	More...
Q9P1Y6	PHD and RING finger domain-containing protein 1	DEG_APCC_KENBOX_2	809:813	RKENP	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons