DegronMD - Q99708(RBBP8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S6N	TCGA-A5-A0GP	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation substituting flanking lysine	0.2222
p.S6N	DO41109	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation substituting flanking lysine	0.2222
p.Y186C	TCGA-AA-3977	COAD	TCGA	RKENP	DEG_APCC_KENBOX_2	178:182	Mutation rewiring degron network	0.2222
p.Y186C	DO8730	COAD	ICGC	RKENP	DEG_APCC_KENBOX_2	178:182	Mutation rewiring degron network	0.2222
p.G37C	TCGA-AP-A0LM	UCEC	TCGA	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.0556
p.G37C	DO43306	UCEC	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.0556
p.A14V	TCGA-B5-A1MX	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.5825
p.A14V	DO41999	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.5825
p.N12K	TCGA-BR-4256	STAD	TCGA	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.1111
p.N12K	TCGA-BR-4256	STAD	TCGA	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778
p.N12K	DO38743	STAD	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.1111
p.N12K	DO38743	STAD	ICGC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778
p.S13C	TCGA-HZ-7919	PAAD	TCGA	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.1389
p.S13C	TCGA-HZ-7919	PAAD	TCGA	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.3056
p.S13C	DO32753	PAAD	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.1389
p.S13C	DO32753	PAAD	ICGC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.3056
p.A470D	DO230309	COCA	ICGC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation altering degron motif	0.6682
p.S10I	DO223028	ESCA	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation blocking phosphorylation signal	0.5
p.S10I	DO223028	ESCA	ICGC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation blocking phosphorylation signal	0.6667
p.R175L	DO228986	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	178:182	Mutation rewiring degron network	0.25
p.G37V	DO229019	LICA	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	20:27	Mutation rewiring degron network	0.0556
p.R177L	DO229041	LICA	ICGC	RKENP	DEG_APCC_KENBOX_2	178:182	Mutation rewiring degron network	0.3056
p.A14S	DO229045	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7588
p.S480F	DO229470	SKCA	ICGC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0556
p.E457K	SIDM00216	Colorectal Carcinoma	GDSC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0833
p.E457K	ACH-000989	Colon/Colorectal Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0833
p.E457K	SNU-175	large intestine	COSMIC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0833
p.S4L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0556
p.S4L	ACH-000860	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0556
p.S4L	NCI-H358	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0556
p.G9E	SIDM00240	Cervical Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.G9E	ACH-002180	Cervical Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.G9E	OMC-1	cervix	COSMIC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.H456R	SIDM01246	Ewing's Sarcoma	GDSC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0556
p.H456R	SIDM00634	Ewing's Sarcoma	GDSC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0556
p.H456R	SIDM01750	Melanoma	GDSC	DKENA	DEG_APCC_KENBOX_2	466:470	Mutation rewiring degron network	0.0556
p.R15G	EN	endometrium	COSMIC	ADTSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7568

Kaplan plot for RBBP8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBBP8

UniProt ID: Q99708

Entrez ID: 5932

Protein name: DNA endonuclease RBBP8 (EC 3.1.-.-) (CtBP-interacting protein) (CtIP) (Retinoblastoma-binding protein 8) (RBBP-8) (Retinoblastoma-interacting protein and myosin-like) (RIM) (Sporulation in the absence of SPO11 protein 2 homolog) (SAE2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBBP8 in