DegronMD

Uniprot ID: Q99708

Source protein: DNA endonuclease RBBP8

Source gene: RBBP8

Class: DEG_APCC_KENBOX_2

Location: 466:470

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8088

ASA_SCORE: 92.14

COIL: 0.753

CONS_SCORE: 0.507

DSS_SCORE: 0.4868

HELIX: 0.1842

FCONS_SCORE: 1.3096

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A470D	DO230309	COCA	ICGC	DKENA	DEG_APCC_KENBOX_2	0.6682
p.S480F	DO229470	SKCA	ICGC	DKENA	DEG_APCC_KENBOX_2	0.0556
p.E457K	SIDM00216	Colorectal Carcinoma	GDSC	DKENA	DEG_APCC_KENBOX_2	0.0833
p.E457K	ACH-000989	Colon/Colorectal Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	0.0833
p.E457K	SNU-175	large_intestine	COSMIC	DKENA	DEG_APCC_KENBOX_2	0.0833
p.H456R	SIDM01246	Ewing's Sarcoma	GDSC	DKENA	DEG_APCC_KENBOX_2	0.0556
p.H456R	SIDM00634	Ewing's Sarcoma	GDSC	DKENA	DEG_APCC_KENBOX_2	0.0556
p.H456R	SIDM01750	Melanoma	GDSC	DKENA	DEG_APCC_KENBOX_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons