DegronMD - P07951(TPM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A22T	TCGA-50-5930	LUAD	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2222
p.A22T	DO25189	LUAD	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2222
p.E23K	TCGA-AA-3864	COAD	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944
p.E23K	TCGA-BT-A0YX	BLCA	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944
p.E23K	DO516	BLCA	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944
p.E23K	DO8490	COAD	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944
p.K15Q	TCGA-CK-4951	COAD	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.6944
p.K15Q	DO10582	COAD	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.6944
p.E26K	TCGA-E6-A1LX	UCEC	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1111
p.E26K	DO41020	UCEC	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1111
p.D28N	TCGA-EB-A44O	SKCM	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.0556
p.D28N	DO47272	SKCM	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.0556
p.E16K	TCGA-ER-A19H	SKCM	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.7022
p.E16K	DO47299	SKCM	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.7022
p.E16Q	TCGA-QK-A6VB	HNSC	TCGA	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.6744
p.E16Q	DO219054	HNSC	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.6744
p.D14H	DO46542	OV	ICGC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation altering degron motif	0.6577
p.K12R	SIDM00878	Breast Carcinoma	GDSC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation blocking ubiquitination signal	0.7222
p.K12R	ACH-000930	Breast Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation blocking ubiquitination signal	0.7222
p.K12R	HCC1569	breast	COSMIC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation blocking ubiquitination signal	0.7222
p.M10V	SIDM00878	Breast Carcinoma	GDSC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2222
p.M10V	ACH-000930	Breast Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2222
p.M10V	HCC1569	breast	COSMIC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.2222
p.E23Q	SIDM00794	Other Solid Cancers	GDSC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944
p.E23Q	ACH-001442	Skin Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944
p.E23Q	A388	skin	COSMIC	DKENA	DEG_APCC_KENBOX_2	14:18	Mutation rewiring degron network	0.1944

Kaplan plot for TPM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPM2

UniProt ID: P07951

Entrez ID: 7169

Protein name: Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPM2 in