DegronMD

Uniprot ID: P07951

Source protein: Tropomyosin beta chain

Source gene: TPM2

Class: DEG_APCC_KENBOX_2

Location: 14:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7068

ASA_SCORE: 77.3

COIL: 0.09

CONS_SCORE: 0.717

DSS_SCORE: 0.4892

HELIX: 0.916

FCONS_SCORE: 1.2584

RIG_SCORE: 0.7557

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A22T	TCGA-50-5930	LUAD	TCGA	DKENA	DEG_APCC_KENBOX_2	0.2222
p.A22T	DO25189	LUAD	ICGC	DKENA	DEG_APCC_KENBOX_2	0.2222
p.E23K	TCGA-AA-3864	COAD	TCGA	DKENA	DEG_APCC_KENBOX_2	0.1944
p.E23K	TCGA-BT-A0YX	BLCA	TCGA	DKENA	DEG_APCC_KENBOX_2	0.1944
p.E23K	DO516	BLCA	ICGC	DKENA	DEG_APCC_KENBOX_2	0.1944
p.E23K	DO8490	COAD	ICGC	DKENA	DEG_APCC_KENBOX_2	0.1944
p.K15Q	TCGA-CK-4951	COAD	TCGA	DKENA	DEG_APCC_KENBOX_2	0.6944
p.K15Q	DO10582	COAD	ICGC	DKENA	DEG_APCC_KENBOX_2	0.6944
p.E26K	TCGA-E6-A1LX	UCEC	TCGA	DKENA	DEG_APCC_KENBOX_2	0.1111
p.E26K	DO41020	UCEC	ICGC	DKENA	DEG_APCC_KENBOX_2	0.1111
p.D28N	TCGA-EB-A44O	SKCM	TCGA	DKENA	DEG_APCC_KENBOX_2	0.0556
p.D28N	DO47272	SKCM	ICGC	DKENA	DEG_APCC_KENBOX_2	0.0556
p.E16K	TCGA-ER-A19H	SKCM	TCGA	DKENA	DEG_APCC_KENBOX_2	0.7022
p.E16K	DO47299	SKCM	ICGC	DKENA	DEG_APCC_KENBOX_2	0.7022
p.E16Q	TCGA-QK-A6VB	HNSC	TCGA	DKENA	DEG_APCC_KENBOX_2	0.6744
p.E16Q	DO219054	HNSC	ICGC	DKENA	DEG_APCC_KENBOX_2	0.6744
p.D14H	DO46542	OV	ICGC	DKENA	DEG_APCC_KENBOX_2	0.6577
p.K12R	SIDM00878	Breast Carcinoma	GDSC	DKENA	DEG_APCC_KENBOX_2	0.7222
p.K12R	ACH-000930	Breast Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	0.7222
p.K12R	HCC1569	breast	COSMIC	DKENA	DEG_APCC_KENBOX_2	0.7222
p.M10V	SIDM00878	Breast Carcinoma	GDSC	DKENA	DEG_APCC_KENBOX_2	0.2222
p.M10V	ACH-000930	Breast Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	0.2222
p.M10V	HCC1569	breast	COSMIC	DKENA	DEG_APCC_KENBOX_2	0.2222
p.E23Q	SIDM00794	Other Solid Cancers	GDSC	DKENA	DEG_APCC_KENBOX_2	0.1944
p.E23Q	ACH-001442	Skin Cancer	CCLE	DKENA	DEG_APCC_KENBOX_2	0.1944
p.E23Q	A388	skin	COSMIC	DKENA	DEG_APCC_KENBOX_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons