DegronMD

Uniprot ID: Q99708

Source protein: DNA endonuclease RBBP8

Source gene: RBBP8

Class: DEG_MDM2_SWIB_1

Location: 20:27

E3 ligase: MDM2

DEGRON score: 0.5675

ASA_SCORE: 55.575

COIL: 0.0203

CONS_SCORE: 0.505

DSS_SCORE: 0.3429

HELIX: 0.9778

FCONS_SCORE: 1.0167

RIG_SCORE: 0.8143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G37C	TCGA-AP-A0LM	UCEC	TCGA	FKDLWTKL	DEG_MDM2_SWIB_1	0.0556
p.G37C	DO43306	UCEC	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	0.0556
p.N12K	TCGA-BR-4256	STAD	TCGA	FKDLWTKL	DEG_MDM2_SWIB_1	0.1111
p.N12K	DO38743	STAD	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	0.1111
p.S13C	TCGA-HZ-7919	PAAD	TCGA	FKDLWTKL	DEG_MDM2_SWIB_1	0.1389
p.S13C	DO32753	PAAD	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	0.1389
p.S10I	DO223028	ESCA	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	0.5
p.G37V	DO229019	LICA	ICGC	FKDLWTKL	DEG_MDM2_SWIB_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99708	DNA endonuclease RBBP8	DEG_MDM2_SWIB_1	20:27	FKDLWTKL	MDM2	0.5675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons