DegronMD

Uniprot ID: Q99708

Source protein: DNA endonuclease RBBP8

Source gene: RBBP8

Class: DEG_SPOP_SBC_1

Location: 14:18

E3 ligase: SPOP

DEGRON score: 0.8958

ASA_SCORE: 75.72

COIL: 0.6846

CONS_SCORE: 0.4152

DSS_SCORE: 0.3899

HELIX: 0.3044

FCONS_SCORE: 0.8229

RIG_SCORE: 0.6471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S6N	TCGA-A5-A0GP	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.2222
p.S6N	DO41109	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2222
p.A14V	TCGA-B5-A1MX	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.5825
p.A14V	DO41999	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.5825
p.N12K	TCGA-BR-4256	STAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.2778
p.N12K	DO38743	STAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2778
p.S13C	TCGA-HZ-7919	PAAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.3056
p.S13C	DO32753	PAAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.3056
p.S10I	DO223028	ESCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.6667
p.A14S	DO229045	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7588
p.S4L	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.S4L	ACH-000860	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.0556
p.S4L	NCI-H358	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.G9E	SIDM00240	Cervical Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.1944
p.G9E	ACH-002180	Cervical Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1944
p.G9E	OMC-1	cervix	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.1944
p.R15G	EN	endometrium	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons